ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Give Your Health a Much-Needed Boost With Geranium

The Role of Resveratrol in Achieving Optimal Health

 
Print Page
Email Article

Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: A systematic review – Source: Journal of Gastroenterology, Feb 18, 2011

  [ 4 votes ]   [ 1 Comment ]
By AC Ford, NJ Talley • www.ProHealth.com • February 21, 2011


Background: The causes of irritable bowel syndrome (IBS) remain obscure. Some investigators have proposed chronic low-grade mucosal inflammation as a potential etiological factor. We performed a systematic review to examine this issue in detail.

Methods: MEDLINE, EMBASE, and EMBASE classic were searched up to December 2010 to identify studies of case-control design applying tests for low-grade inflammation to either full-thickness intestinal or endoscopic mucosal biopsies from patients with IBS.

Controls were required to be healthy individuals, or asymptomatic patients undergoing investigation for reasons other than the reporting of upper or lower gastrointestinal symptoms. Individual study results were summarized descriptively.

Results: The literature search identified 1,388 citations, of which 16 studies were eligible for inclusion. Individual study results were diverse, partly as a consequence of the different surrogate markers for inflammatory mechanisms studied. Mast cells, T lymphocytes, B lymphocytes, and mucosal cytokine production all appeared altered among cases with IBS in individual studies, while no study demonstrated a significant difference in numbers of plasma cells, neutrophils, or eosinophils.

Some studies suggested a relationship between mast cell abnormalities and symptom severity and frequency, as well as co-existent fatigue and depression. [Note: mast cells are white blood cells that play a role in the immune system. When stimulated they release chemicals that signal infection or injury and cause an inflammation in the area.]

Studies were limited by the lack of comparability of controls, and the fact that most were conducted in highly selected groups of patients with IBS.

Conclusions:
Low-grade mucosal inflammation, particularly mast cell activation, may be a contributory factor in the pathogenesis of IBS.

Mast cell stabilizers warrant further assessment as a potential therapy in the condition. [Note: Mast cell stabilizers are used, for example, to keep mast cells from releasing the chemicals that cause inflammation - e.g., release of histamine in some allergic disorders.]

Source: Journal of Gastroenterology, Feb 18, 2011.  PMID: 21331765, by Ford AC, Talley NJ. Leeds Gastroenterology InstituteLeeds General Infirmary, Great George Street, Leeds, UK, [Email: alexf12399@yahoo.com]





Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®


Article Comments Post a Comment

mast cells = infection
Posted by: Sandy10m
Mar 5, 2011
I can't believe they're actually talking about inhibiting the mast cells in the intestines. Mast cells are activated to fight an infection, and histamine has a similar job. So, they want to turn them off? Why not try to find and treat the infection instead? Oh, right, because the MD doctors don't believe in a fungal infection of the intestines, even though hundreds of us have already proven that we have a fungal infection. I was fortunate to figure out how to cure mine, finally. It only took me 5 years of trial and error. How about a study on a trial of anti-fungals (oral powdered Nystatin, mixed in water 3 times per day between meals, amount based upon body weight, plus 2 weeks of daily oral Diflucan 100 mg to get the process started) combined with a Caveman/Paleolithic diet? Now THAT would be interesting science.
Reply Reply
 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map