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Heightened Risk of Many Key Allergies in Youths Linked to Low Vitamin D

  [ 6 votes ]   [ Discuss This Article ] • February 24, 2011

A national study of more than 3,000 US children shows that low vitamin D levels are associated with increased likelihood that children will develop allergies, according to a paper published Feb 17 by the Journal of Allergy and Clinical Immunology.(1)

A research collaborative headed by Michal Melamed, MD, at Albert Einstein College of Medicine looked at the serum vitamin D levels in blood collected in 2005-2006 from a nationally representative sample of more than 3,100 children and adolescents and 3,400 adults. The samples are derived from the National Health and Nutrition Examination Survey (NHANES), a program of studies designed to assess the health and nutritional status of adults and children in the United States.

The survey is unique in that it combines interviews, physical examinations and laboratory studies. One of the blood tests assessed was sensitivity to 17 different allergens by measuring levels of Immunoglobulin E (IgE), a protein made when the immune system responds to allergens.

When the resulting data was analyzed by Einstein researchers, no association between vitamin D levels and allergies was observed in adults. But for young people under age 21, low vitamin D levels correlated with sensitivity to 11 of the 17 allergens tested, including both environmental allergens (e.g., ragweed, oak, dog, cockroach) and food allergens (e.g., peanuts).

For example, children who had vitamin D deficiency (defined as less than 15 nanograms of vitamin D per milliliter of blood), were 2.4 times as likely to have a peanut allergy than were children with sufficient levels of vitamin D (more than 30 nanograms of vitamin D per milliliter of blood).

The research shows only an association and does not prove that vitamin D deficiency causes allergies in children, Dr. Melamed cautions.

Nevertheless, she says children should certainly consume adequate amounts of the vitamin, and  "The latest dietary recommendations calling for children to take in 600 IU of vitamin D daily should keep them from becoming vitamin-D deficient."


1. "Vitamin D levels and food and environmental allergies in the United States: Results from NHANES 2005-2006."

Source: Albert Einstein College of Medicine, New York, Feb 24, 2011

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