ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Mediterranean diet associated with lower risk of aggressive prostate cancer

 
Print Page
Email Article

Quercetin's Effects on Intestinal Polyp Multiplicity and Macrophage Number in the Apc(Min/+) Mouse - Source: Nutrition and Cancer, Mar 2011

  [ 17 votes ]   [ Discuss This Article ]
By EA Murphy, et al. • www.ProHealth.com • March 16, 2011


[Note: quercetin is a plant-derived ‘flavonoid’ chemical (plentiful in green & black tea, red wine & grapes, onions, apples, broccoli, etc.) and studies indicate it supports anti-inflammatory and antioxidant processes, according to the American Cancer Society.]

Numerous in vitro studies argue for quercetin's chemopreventive potential in colon cancer; however, experimental studies in rodents are limited.

Macrophages play a role in tumorigenesis [tumor formation], but the effects of quercetin on macrophage infiltration in colon cancer is unknown. [When T cells recognize tumor cells, they activate macrophages whose job it is to engulf and digest cells in the local area. Thus macrophage activation is a measure of tumor cell activity.]

We examined the effects of quercetin on intestinal polyp multiplicity and macrophage number in Apc(Min/+) mice. [A special mutant mouse strain that develops colon cancer.]

Apc(Min/+) mice were assigned to placebo or quercetin (n = 8/group) groups.

Mice were given a placebo or quercetin (0.02%) diet from 4 to 20 weeks of age, after which:

• Intestines were analyzed:

- For polyp number and size in the small intestine (Sections 1-4) and colon (Section 5)

- And for macrophage number in the small intestine (Sections 1 and 3).

• Spleen weight was determined as a marker of systemic inflammation.

Quercetin decreased total intestinal polyps by 67% (P < 0.05).

Specifically, quercetin reduced intestinal polyps in categories >2 mm (69%) and 1-2 mm (79%; P < 0.05), and in Sections 2 (75%), 3 (80%), and 4 (79%; P < 0.05).

Quercetin also decreased macrophage number in Sections 1 (57%) and 3 (81%), and spleen weight (P < 0.05).

These data suggest that quercetin can reduce polyp number and size distribution in the Apc(Min/+) mouse and that these effects may be related to a reduction in macrophage infiltration.

Source: Nutrition and Cancer, Mar 2011;1(1). PMID: 21391122, by Murphy EA, Davis JM, McClellan JL, Carmichael MD. Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA.





Post a Comment

Featured Products From the ProHealth Store
Quercetin / Bromelain Complex Optimized Curcumin Longvida® Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Quercetin / Bromelain Complex Quercetin / Bromelain Complex
Balances Histamine Levels Naturally

Natural Remedies

Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
How One Tiny Molecule Turned into One Huge Health Breakthrough How One Tiny Molecule Turned into One Huge Health Breakthrough
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map