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The Retrovirus XMRV in Prostate Cancer and Beyond – Source: The FASEB Journal, Apr 2011

  [ 11 votes ]   [ 1 Comment ]
By Robert H Silverman • • March 21, 2011

[Note: This is an abstract of research to be presented at the American Federation of Societies for Experimental Biology (FASEB) annual meeting April 9-13.]

Genetic evidence that the antiviral protein, RNase L, suppresses hereditary prostate cancer led us to examine the possibility that chronic viral infections might predispose men to prostate cancer.

These studies resulted in identification of a previously unknown gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV).

• Currently, several different research teams have published both PCR-based and non-PCR-based evidence in support of the hypothesis that XMRV is a bona fide human virus.

• In addition, some but not all studies associated XMRV infections with either prostate cancer or chronic fatigue syndrome-myalgic encephalomyelitis (CFS-ME).

• XMRV replication is stimulated by androgen and inhibited by interferon through host restriction factors, such as apobec3, tetherin and RNase L.

• Studies in rhesus macaques showed that intravenous inoculation with XMRV caused wide-spread dissemination of the virus in lymphoid and non-lymphoid tissues (including prostate), a humoral immune response and a chronic persistent infection.

While gammaretroviruses cause cancer and neurological disease in animals it remains unknown if XMRV is a cause of either prostate cancer or CFS-ME.

Source: The FASEB Journal, Apr 2011. Meeting abstract, Supplement 429.3. Silverman RH. Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA.

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Article Comments Post a Comment

xmrv is still only hype and is still not proven science....
Posted by: aidanwalsh
Mar 21, 2011
let us all hope that this meeting put this theory to rest for good or the final proof that xmrv is a cause. until science completely 'replicates'those initial findings i will stay a non-believer in xmrv hype...meanwhile i will stay the full path with as this iranian doctore/researcher who discovered the watercure stated that all doctors/scientists need to go back to school to retrain and understand fully 'the body's many cries for water'...he even said that scientific findings today are flawed because of this misunderstanding of water in the human body which results in 'false' results in research methods...this is something i believe in very much and to me out of all the news on cfs over the last few decades is the only research work that makes any sense although there still could be alink to ciguatera (epitope) toxins with low level radiation poison but i still feel the watercure is the right direction until i can see more proof not hype....sincerely aidan walsh southampton, u.k. god bless all of you who are sick and especially the children who suffer each and everyday and are still dismissed....x x
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