ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Give Your Health a Much-Needed Boost With Geranium

The Role of Resveratrol in Achieving Optimal Health

Could Coconut Oil Help Reduce Antibiotics?

 
Print Page
Email Article

Study unravels new mechanism by which cannabinoids suppress immune function; labels them 'double-edged sword'

  [ 24 votes ]   [ 3 Comments ]
www.ProHealth.com • April 2, 2011


Compounds found in the cannabis plant can trigger a suppression of the body’s immune functions, creating greater susceptibility to certain types of cancers and infections, according to research led by the eminent immunologist
Dr. Prakash Nagarkatti at the University of South Carolina School of Medicine.

The findings also point to the possibility of using such compounds, currently used legally in some places for pain relief and other medical purposes - as a treatment for a large number of additional clinical disorders that benefit from a suppressed immune response, including importantly rheumatoid arthritis, multiple sclerosis and lupus.

The research, published in the European Journal of Immunology, focuses on a group of cannabinoid compounds, including THC (delta-9 tetahydrocannabinol).(1)

“Cannabis is one of the most widely used drugs of abuse worldwide, and it is already believed to suppress immune functions making the user more susceptible to infections and some types of cancer,” Dr. Nagarkatti said.

“We believe the key to this suppression is a unique type of immune cell, which has only recently been identified by immunologists - called myeloid-derived suppressor cells, MDSCs.”

• While most immune cells fight against infections and cancers to protect the host, MDSCs actively suppress the immune system.

• The presence of these cells is known to increase in cancer patients,

• And it is believed that MDSCs may suppress the immune system against cancer therapy, actually promoting cancer growth.

Dr. Nagarkatti’s team demonstrated that cannabinoids can trigger a massive number of MDSCs through activation of cannabinoid receptors.

“Our research for the first time demonstrates that marijuana cannabinoids can activate a unique type of immune cell, and the job of these cells is to suppress the immune response,” he says.

Suppressing the immune response is important for treating a large number of ailments, including arthritis, multiple sclerosis, lupus and allergies.

“In these, your immune system gets activated and starts destroying your own cells and tissues. You have to try to suppress your immune response,” Dr. Nagarkatti explains. “In such instances, there is a need to develop drugs that can suppress the immune response.”

“Marijuana cannabinoids present us with a double-edged sword,” he adds. “On one hand, due to their immunosuppressive nature, they can cause increased susceptibility to cancer and infections. However, further research of these compounds could provide opportunities to treat a large number of clinical disorders where suppressing the immune response is actually beneficial.”

The research was funded by the National Institutes of Health’s National Institute on Drug Abuse. Co-authors were Dr. Venkatesh Hegde and Dr. Mitzi Nagarkatti.
____

1. See abstract & full text article: “Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties.”)

Source: University of South Carolina news release, Dec 2, 2010




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®


Article Comments Post a Comment

Prescription
Posted by: janquito
Apr 6, 2011
I rather doubt I would be able to talk my doc into giving me a prescription and I wouldn't want to smoke this illegally even though I did as a teen. I feel if this is something that a person could use for their illness, they should be allowed to get it legally. Seems there are so many ways of getting cancer that I am starting to not believe half of what is said causes it. One takes a chance with so many items that, what's one more thing?
Reply Reply

Why is it illegal?
Posted by: LocalMan
Apr 10, 2011
The (now age-old) question is: Why is cannabis illegal to begin with, when tobacco and alcohol are not? Until the entire nation learns the honest answer to this question, the hemp plant, with all of its benefits, will remain an unfortunate illegal alien here. Huge amounts of corporate cash are spent every year to keep it out of the fields and off the market. Follow the bouncing dollar signs, and you will learn who wants it illegal, and why. I did it, so can you.
Reply Reply

Study
Posted by: toked
Aug 19, 2011
Complete horse manure. This would negate thousands of years of contrary observation and current observations. Dr. Prakash Nagarkatti is currently testing cannabis compounds on patients with leukemia. Seems sort of contrary, doesn't it?
Reply Reply


Post a Comment

 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
Breaking Through the Mental Fog Breaking Through the Mental Fog
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map