ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Meet Your Weight Loss Goals

AMA journal associates iron deficiency with hearing loss

Why the Mediterranean Diet Is so Successful

 
Print Page
Email Article

Lubiprostone for the Treatment of Adults with Constipation and Irritable Bowel Syndrome – Source: Digestive Diseases and Sciences, Apr 27, 2011

  [ 17 votes ]   [ Discuss This Article ]
By Ron Schey, Satish SC Rao • www.ProHealth.com • April 29, 2011


Chronic constipation and IBS-C are two of the most common functional bowel disorders encountered by primary care providers and gastroenterologists, affecting up to 27% of the population in Western countries.

The treatment of these disorders is often empiric [whatever is found to be effective] and most current therapies are indicated for episodic constipation. Over time, most patients become refractory [resistant] to one or more laxatives.

Lubiprostone (Amitiza) has been approved by the US Food and Drug Administration (FDA) for the treatment of chronic-idiopathic constipation. It is an oral bicyclic fatty acid that selectively activates type 2 chloride channels in the apical membrane of the intestinal epithelial cells, hence stimulating chloride secretion, along with passive secretion of sodium and water, inducing peristalsis and laxation [loosening and movement], without stimulating gastrointestinal smooth muscle.

Several trials have shown it to be effective in the treatment of chronic idiopathic constipation, and recently also IBS-C.

It has little systemic absorption [confined within gut] and is almost free of any serious adverse effects. However, occasionally can cause nausea.

Based on the available evidence, it is reasonable to conclude that lubiprostone should be added to the short list of evidence-based pharmacotherapies for chronic constipation and IBS-C.

Given the overlap between chronic constipation and IBS-C, clinicians can consider two strategies when deciding on the initial dose of lubiprostone. Based on current product labeling, it is recommended that:

• 8 micrograms twice daily be started in patients with IBS-C, whereas

• 24 micrograms twice daily be used in those with chronic constipation.

Thus far, lubiprostone offers a novel approach to our therapeutic armamentarium.

However, there is a need for more drugs with different mechanisms of action, in order to treat constipation that is often multifunctional [involving multiple factors].

Source:
Digestive Diseases and Sciences, Apr 27, 2011. PMID: 21523369, by  Schey R, Rao SS. Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA. [Email: ron-schey@uiowa.edu]





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map