ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Lutein — An Important Nutrient for Eye and Brain Health

Hop Oil: A Safe Sleep Aide

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

 
Print Page
Email Article

New Drug Relieves Constipation by Conserving Body’s Natural Bile Acids – Mayo Clinic

  [ 12 votes ]   [ 3 Comments ]
www.ProHealth.com • May 10, 2011


Constipation affects nearly 30 million Americans – especially those who are taking opioid drugs, have limited mobility, or have IBS with constipation. The problem costs more than $1 billion annually to evaluate and treat, and while it’s not often life threatening, the pain, bloating, discomfort, and straining associated with constipation lead sufferers to focus on one thing - relief.

Mayo Clinic researchers recently had success in the clinical trial of a new medication shown to provide relief from constipation in a way that capitalizes on the body's natural processes.

The drug, called A3309, targets bile acid recycling in the body.

• Bile acids, created in the liver and released into the digestive system, aid in breaking down fats and absorbing them into the body.

• Bile acids also are natural laxatives that promote bowel movements by softening stool and speeding up how fast stool moves through the colon.

• During digestion, most bile acids are absorbed back into the blood in the lower small intestines for recycling, leaving very little bile acids to leak into the colon to help facilitate bowel movements.

• A3309 works by inhibiting bile acid absorption in the small intestines, allowing more bile acids to enter the colon to stimulate bowel movements.

"The new medication is a novel approach which allows the delivery to the colon of normal substances produced by the patient's own liver to induce a laxative effect," says Mayo gastroenterologist Michael Camilleri, MD,  who led the study.

In their Phase II, randomized, double-blind, placebo-controlled study, the research team tested the effectiveness of A3309 for two weeks in patients with constipation.

The study yielded promising results, according to co-researcher Dr. Banny Wong, MD, who reported the study findings at the Digestive Disease Week conference May 10 in Chicago.

• The drug sped up the movement of stool through the colon.

• Patients with constipation who took A3309, compared to those who received placebo, reported significantly less straining and softer stool during bowel movements.

• The main side effect of A3309 was abdominal discomfort and pain before a bowel movement and subsiding subsequently.

The next step in the drug's development will be Phase III studies involving more people and a longer treatment duration, says Dr. Wong.

Source: Mayo Clinic news release, May 10, 2011




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Vitamin D3 Extreme™ FibroSleep™


Article Comments Post a Comment

constipation and the new med
Posted by: harboreen
May 12, 2011
I'm happy to know these studies are going on and am more than willing to give this one a try as soon as it's available. We joke about constipation but for sure it's a major issue and even more pain in addition to that of fibro. IBS sufferers and those of us who's lives depend on the use of these meds will no doubt welcome this open arms! It couldn't arrive too soon!
Reply Reply

the answer is not another drug
Posted by: Sandy10m
May 13, 2011
I wish we'd see some studies about the natural ways to solve these problems before resorting to drugs. What about taking magnesium citrate? That almost always helps keep bowels moving, and most people with ME/CFS/FS have a magnesium deficiency anyway. What about L-ascorbate (a form of Vitamin C)? There are many other herbals and supplements that are way more friendly to the body than more drugs.
Reply Reply

constipation drug vs mag citrite
Posted by: harboreen
May 15, 2011
I agree natural is the way to go however help is needed now and although Magnesium Citrate can be helpful it is not a product you'd use daily, or often for that matter. It can be very bad for the system, robbing your body of nutrients and knocking your system even more out of wack causing more issues. Be careful!
Reply Reply


Post a Comment

 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
The Genetic Mutation That May Compromise Your Health - And What to Do About It The Genetic Mutation That May Compromise Your Health - And What to Do About It

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map