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New Drug Relieves Constipation by Conserving Body’s Natural Bile Acids – Mayo Clinic

  [ 12 votes ]   [ 3 Comments ] • May 10, 2011

Constipation affects nearly 30 million Americans – especially those who are taking opioid drugs, have limited mobility, or have IBS with constipation. The problem costs more than $1 billion annually to evaluate and treat, and while it’s not often life threatening, the pain, bloating, discomfort, and straining associated with constipation lead sufferers to focus on one thing - relief.

Mayo Clinic researchers recently had success in the clinical trial of a new medication shown to provide relief from constipation in a way that capitalizes on the body's natural processes.

The drug, called A3309, targets bile acid recycling in the body.

• Bile acids, created in the liver and released into the digestive system, aid in breaking down fats and absorbing them into the body.

• Bile acids also are natural laxatives that promote bowel movements by softening stool and speeding up how fast stool moves through the colon.

• During digestion, most bile acids are absorbed back into the blood in the lower small intestines for recycling, leaving very little bile acids to leak into the colon to help facilitate bowel movements.

• A3309 works by inhibiting bile acid absorption in the small intestines, allowing more bile acids to enter the colon to stimulate bowel movements.

"The new medication is a novel approach which allows the delivery to the colon of normal substances produced by the patient's own liver to induce a laxative effect," says Mayo gastroenterologist Michael Camilleri, MD,  who led the study.

In their Phase II, randomized, double-blind, placebo-controlled study, the research team tested the effectiveness of A3309 for two weeks in patients with constipation.

The study yielded promising results, according to co-researcher Dr. Banny Wong, MD, who reported the study findings at the Digestive Disease Week conference May 10 in Chicago.

• The drug sped up the movement of stool through the colon.

• Patients with constipation who took A3309, compared to those who received placebo, reported significantly less straining and softer stool during bowel movements.

• The main side effect of A3309 was abdominal discomfort and pain before a bowel movement and subsiding subsequently.

The next step in the drug's development will be Phase III studies involving more people and a longer treatment duration, says Dr. Wong.

Source: Mayo Clinic news release, May 10, 2011

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Article Comments Post a Comment

constipation and the new med
Posted by: harboreen
May 12, 2011
I'm happy to know these studies are going on and am more than willing to give this one a try as soon as it's available. We joke about constipation but for sure it's a major issue and even more pain in addition to that of fibro. IBS sufferers and those of us who's lives depend on the use of these meds will no doubt welcome this open arms! It couldn't arrive too soon!
Reply Reply

the answer is not another drug
Posted by: Sandy10m
May 13, 2011
I wish we'd see some studies about the natural ways to solve these problems before resorting to drugs. What about taking magnesium citrate? That almost always helps keep bowels moving, and most people with ME/CFS/FS have a magnesium deficiency anyway. What about L-ascorbate (a form of Vitamin C)? There are many other herbals and supplements that are way more friendly to the body than more drugs.
Reply Reply

constipation drug vs mag citrite
Posted by: harboreen
May 15, 2011
I agree natural is the way to go however help is needed now and although Magnesium Citrate can be helpful it is not a product you'd use daily, or often for that matter. It can be very bad for the system, robbing your body of nutrients and knocking your system even more out of wack causing more issues. Be careful!
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