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A combination of green tea extract and L-theanine improves memory and attention in subjects with mild cognitive impairment: A double-blind placebo-controlled study – Source: Journal of Medicinal Food, Apr 2011

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By SK Park, et al. • www.ProHealth.com • May 13, 2011


[Note: Studies indicate green tea extract’s potent polyphenolic compounds help neutralize the free radicals that threaten fragile brain cells and DNA; and that the amino acid L-theanine - one of the main compounds in green tea - supports increased levels of the calming brain chemical GABA and the mood enhancing chemical dopamine.]

A combination of green tea extract and L-theanine (LGNC-07) has been reported to have beneficial effects on cognition in animal studies.

In this randomized, double-blind, placebo-controlled study, the effect of [the green tea extract & L-theanine combination] LGNC-07 on memory and attention in subjects with mild cognitive impairment (MCI) was investigated.

Ninety-one MCI subjects whose Mini Mental State Examination-K (MMSE-K) scores were between 21 and 26 and who were in either stage 2 or 3 on the Global Deterioration Scale were enrolled in this study.

The treatment group (13 men, 32 women; 57.58 +/- 9.45 years) took 1,680 mg of LGNC-07, and the placebo group (12 men, 34 women; 56.28 +/- 9.92 years) received an equivalent amount of maltodextrin and lactose for 16 weeks.

Neuropsychological tests (Rey-Kim memory test and Stroop color-word test) and electroencephalography were conducted to evaluate the effect of LGNC-07 on memory and attention.

Further analyses were stratified by baseline severity to evaluate treatment response on the degree of impairment (MMSE-K 21-23 and 24-26).

• LGNC-07 led to improvements in memory by marginally increasing delayed recognition in the Rey-Kim memory test (P = .0572).

• Stratified analyses showed that LGNC-07 improved memory and selective attention by significantly increasing the Rey-Kim memory quotient and word reading in the subjects with MMSE-K scores of 21-23 (LGNC-07, n = 11; placebo, n = 9).

Electroencephalograms were recorded in 24 randomly selected subjects hourly for 3 hours in eye-open, eye-closed, and reading states after a single dose of LGNC-07 (LGNC-07, n = 12; placebo, n = 12). Brain theta waves, an indicator of cognitive alertness, were increased significantly in the temporal, frontal, parietal, and occipital areas after 3 hours in the eye-open and reading states.

Therefore, this study suggests that [a combination of green tea extract and L-theanine] has potential as an intervention for cognitive improvement.

Source: Journal of Medicinal Food, Apr 2011; Source: Journal of Medicinal Food, Apr 2011. PMID: 21303262, by Park SK, Jung IC, Lee WK, Lee YS, Park HK, Go HJ, Kim K, Lim NK, Hong JT, Ly SY, Rho SS. LG Household and Health Care Co., Ltd., Daejeon, Korea.





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