ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Fighting Heartburn and Gerd Naturally – And Safely!

 
Print Page
Email Article

Depression patients may benefit from supplementing with glutathione, NAC, & selenium, according to Michael Maes, et al.

  [ 12 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 16, 2011


Article Title
Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: Another pathway that may be associated with coronary artery disease and neuroprogression in depression – Source: Neuroendocrinology Letters, Apr 9, 2011

By Michael Maes, et al.

Abstract

Background: Major depression and myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) are two disorders accompanied by an upregulation of the inflammatory and oxidative and nitrosative (IO&NS) pathways and a decreased antioxidant status.

Moreover, depression is accompanied by disorders in inflammatory and neuroprogressive (IN-PRO) pathways.

Methods: This study examines whole blood glutathione peroxidase (GPX) in depression and in ME/CFS;

GPX is an enzyme that:

• Reduces hydroperoxides by oxidizing glutathione

• And consequently protects the cells from oxidative damage [is an antioxidant].

Blood was sampled in 39 patients with depression, 40 patients with ME/CFS, and 24 normal volunteers.

Whole blood was analyzed for GPX activity using the Ransel assay (Randox). Severity of illness was measured by means of the Hamilton Depression Rating Scale (HDRS) and the Fibromyalgia and Chronic Fatigue Syndrome Rating Scale (FF scale).

Results: We found that:

• Whole blood GPX activity was significantly (p=0.001) lower in depressed patients than in normal controls. [Probability that this finding resulted by chance about 1 in 1,000.]

• And that there were no significant differences between ME/CFS and controls.

• In depression and ME/CFS, there were significant and inverse relationships between GPX activity and the FF items, depressed mood and autonomic symptoms [meaning lower GPX activity was associated with more pronounced symptoms, and vice-versa].

• In depression, there were significant and negative correlations between whole blood GPX and the HDRS score and autonomic symptoms [again, lower GPX, more severe symptoms, & vice-versa].

Discussion:

The results show that lowered whole blood glutathione peroxidase (GPX) activity contributes to the lowered antioxidant status in depression.

Since GPX activity is a predictor of neuroprogression and coronary artery disease (CAD), lowered GPX activity in depression contributes to the IN-PRO pathways and the comorbidity between depression and CAD.

Our results suggest that patients with depression would benefit from Ebselen or a supplementation with glutathione, N-Acetyl-L-Cysteine [NAC] and selenium.

Source: Neuroendocrinology Letters, Apr 9, 2011;32(2). PubMed ID: 21552194, by Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. Piyavate Hospital, Bangkok, Thailand.





Post a Comment

Featured Products From the ProHealth Store
N-Acetyl Cysteine (NAC) FibroSleep™ Selenium


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
N-Acetyl Cysteine (NAC) N-Acetyl Cysteine (NAC)
An effective detoxifying nutrient and antioxidant
Selenium Selenium
Activates antioxidant glutathione for cell protection
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map