ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

More evidence for calorie restriction’s longevity effect

Vitamin D deficiency increases risk of chronic headache

Wearable biosensors can flag illness, Lyme disease, risk for diabetes; low airplane oxygen

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Get the Most From Your Green Tea

Affordable Care Act made cancer screening more accessible for millions, study finds

 
Print Page
Email Article

What initiates the formation of senile plaques? The origin of Alzheimer-like dementias in capillary hemorrhages - Source: Medical Hypotheses, Sep 2008

  [ Not Yet Rated ]   [ Discuss This Article ]
By Jonathan Stone • www.ProHealth.com • August 4, 2008


Although the key pathologies of the demented brain have been known for over a century, and the senile plaque is the focus of intense research, the mechanisms that cause plaques to form are not established.

This paper proposes that the formation of each plaque is initiated by bleeding from a cerebral capillary, which creates the conditions for formation of an amyloid-rich plaque. Specifically, it is argued that ischemia caused by the hemorrhage upregulates the expression of beta-amyloid by local neural cells, and that hemoglobin released into the neuropil binds to the beta-amyloid and promotes its oligomerisation [oligomers interfere with neurotransmission].

The premise that the event that initiates plaque formation is vascular explains:

  • Why the risk factors for Alzheimer’s disease and cardiovascular diseases overlap;
  • Why drugs and lifestyle changes with vaso-protective effects protect against dementia;
  • And why oxidative stress is prominent early in the genesis of Alzheimer-like dementias.

The vascular premise also suggests that the anatomical substrate for the spread of plaque formation is the capillary bed of the cerebral cortex, and provides an explanation of why plaque formation is age-related, occurring as the capillary bed becomes fragile with age.

The more specific premise, that hemorrhage creates the conditions for plaque formation, explains many of the features of plaques:

  • Their small and relatively uniform size, each being the site of a capillary bleed;
  • Why plaques form around capillaries;
  • Why haem [responsible for blood’s red color] is found in every plaque;
  • Why an inflammatory response is prominent where plaques form;
  • Why plaque formation and hemorrhagic stroke commonly co-occur in both sporadic and familial dementias;
  • Why plaques form around vessels in mouse models of plaque formation induced by transgenes that mimic the mutations that cause familial disease;
  • Why the acute petechial bleeding caused by brain trauma can lead to the formation of plaques.

The hypothesis also suggests an explanation of how Alzheimer-like dementias can occur without plaque formation, as when the cerebral capillaries become blocked or constricted in flow, without hemorrhage.

Advances in the prevention of dementia will be gained, it is argued, from understanding of why the cerebral capillary bed becomes unstable with age, and how that instability can be prevented, delayed or slowed.

Advances in the treatment of dementia will be gained from techniques that minimize the neural damage caused by a multitude of tiny strokes.

Source: Medical Hypotheses, Sep 2008. 71(3), 347-359. PMID: 18524497 Stone J. Discipline of Physiology, Bosch Institute and School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia. [E-mail: jonstone@eye.usyd.edu.au]





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® FibroSleep™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map