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Antioxidant Suggestions For Down-regulation of the NO/ONOO- Cycle from Dr. Martin Pall, PhD

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By Martin L. Pall, PhD • • June 12, 2007

Martin Pall, PhD, School of Molecular Biosciences, Washington State University, has identified the NO/ONOO- cycle (the stress-induced increase in the levels of nitric oxide and its oxidant product peroxynitrite, and the biochemical vicious cycle that keeps these levels chronically elevated) as a key mechanism underlying oxidative stress. [See the article: "Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other 'Unexplained Illnesses?"]

Below are individual and full-spectrum antioxidant preparations that together may assist in down-regulating this NO/ONOO- cycle mechanism. These suggestions are intended as nutritional support, not as a replacement for medical treatment of any condition. [Dr. Pall worked with a leading supplement research company to develop these preparations and, working with this company to help make the formulations available, ProHealth has arranged to offer all of them in our store.]

CoQ-Gamma E with Tocotrienols & Carotenoids
Take 1 softgel daily, in the morning. Some individuals may increase to 1 softgel two times daily, morning and mid-day. [Includes the antioxidants CoQ-10, vitamin E, gamma tocopherol.]

Take 2 capsules, three times daily, with or following meals. This is a multivitamin/mineral with acetyl-L-carnitine and R-alpha-lipoic acid.

Take 1 capsule, three times daily, spread out over the day. Take one capsule in the middle of the night if one wakes up. Flavonoids are rapidly absorbed and excreted, substantially elevating blood levels for roughly four hours. Divided dosages can significantly support anti-oxidant levels in the body for longer periods. [Includes extracts of milk thistle seed, bilberry, ginkgo leaves, grape seed, green tea, cranberry juice, and hawthorne berry/leaf/flower.]

NAC Enhanced Antioxidant Formula
Take 1 tablet, three times daily, following or with meals. At this dose, the modest amount of N-acetyl-L-cysteine will help avoid possible excitotoxicity.

Ultra EPA fish oil concentrate
Take 1 softgel, one or two times daily. Take the first dose with the CoQ-Gamma E with Tocotrienols & Carotenoids. Lowers induction of inducible nitric oxide synthase, and has anti-inflammatory properties.

* * * *

Initially, it may be desirable to introduce these supplements one at a time, so if one produces a negative response, that component can be identified and discontinued for a period of time (or permanently). The initial regimen would change every three days, as follows:

• Start by taking 1 CoQ-Gamma E with Tocotrienols & Carotenoids, one time daily in the morning, for three days.

• Add 1 MVM-A, three times daily, for three days.

• Add 1 MVM-A, three times daily, for three days, to a total of six daily.

• Add 1 FlaviNOx™, three times daily, for three days.

• Add 1 NAC Enhanced Antioxidant Formula, three times daily, for three days.

• Add 1 Ultra EPA fish oil concentrate, one time daily, in the morning.

The rationale for these nutritional components and how they support antioxidant function is discussed in Dr. Pall’s book, Explaining ‘Unexplained Illnesses’.

Note: These statements have not been evaluated by the U.S. Food and Drug Administration. Dr. Pall cautions that he is a PhD, not an MD, and none of this should be viewed as medical advice. The supplements included in this protocol are not sold as a treatment or cure for any disease. It is very important that you make no change in your healthcare plan or regimen without researching and discussing it with your professional healthcare team.

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