ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fight Back! Win the War Being Waged Against Your Immune System

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Simvastatin vs therapeutic lifestyle changes and supplements: Randomized primary prevention trial - Source: Mayo Clinic Proceedings, Jul 2008

  [ Not Yet Rated ]   [ Discuss This Article ]
By DJ Becker, et al. • • July 18, 2008

[Note: Statins, such as simvastatin, are cholesterol-lowering prescription drugs.]

Objective: To compare the lipid-lowering effects of an alternative regimen (lifestyle changes, red yeast rice, and fish oil) with a standard dose of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin).

Patients and Methods: This randomized trial enrolled 74 patients with hypercholesterolemia [high cholesterol] who met Adult Treatment Panel III criteria for primary prevention using statin therapy.

All participants were randomized to an alternative treatment group (AG) or to receive simvastatin (40 mg/d) in this open-label trial conducted between April 1, 2006, and June 30, 2006.

The alternative treatment included:

  • Therapeutic lifestyle changes,
  • Ingestion of red yeast rice,
  • And fish oil supplements, for 12 weeks.
  • The simvastatin group received medication and traditional counseling.

    The primary outcome measure was the percentage change in low-density lipoprotein cholesterol (LDL-C)[referred to as 'bad' cholesterol]. Secondary measures were changes in other lipoproteins and weight loss.


  • There was a statistically significant reduction in LDL-C levels in both the AG (-42.4%+/-15%) (P<.001) and the simvastatin group (-39.6%+/-20%) (P<.001).
  • No significant differences were noted between groups.
  • The alternative treatment group also demonstrated significant reductions in triglycerides (-29% vs -9.3%; 95% confidence interval, -61 to -11.7; P=.003) and weight (-5.5% vs -0.4%; 95% confidence interval, -5.5 to -3.4; P<.001) compared with the simvastatin group.
  • Conclusion: Lifestyle changes combined with ingestion of red yeast rice and fish oil reduced LDL-C in proportions similar to standard therapy with simvastatin.

    Pending confirmation in larger trials, this multifactorial, alternative approach to lipid lowering has promise for a subset of patients unwilling or unable to take statins.

    Source: Mayo Clinic Proceedings. Jul 2008;83(7):758-64. PMID: 18613992, by Becker DJ, Gordon RY, Morris PB, Yorko J, Gordon YJ, Li M, Iqbal N. Division of Cardiology, Chestnut Hill Hospital, University of Pennsylvania Health System, Philadelphia, PA, USA. [E-mail:]

    Post a Comment

    Featured Products From the ProHealth Store
    Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil

    Looking for Vitamins, Herbs and Supplements?
    Search the ProHealth Store for Hundreds of Natural Health Products

    Article Comments

    Be the first to comment on this article!

    Post a Comment

    Natural Pain Relief Supplements

    Featured Products

    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
    Ultra concentrated source of essential fish oils
    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    FibroSleep™ FibroSleep™
    The All-in-One Natural Sleep Aid

    Natural Remedies

    The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
    Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
    Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
    Complete and Natural Menopause Relief Complete and Natural Menopause Relief
    Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    Credit Card Processing
    Be the first to know about new products, special discounts and the latest health news. *New subscribers only

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map