ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

Why the Mediterranean Diet Is so Successful

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

Wearable biosensors can flag illness, Lyme disease, risk for diabetes; low airplane oxygen

VIDEO: The Best Brain Foods That Help Increase Your Memory!

More evidence for calorie restriction’s longevity effect

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

 
Print Page
Email Article

Simvastatin vs therapeutic lifestyle changes and supplements: Randomized primary prevention trial - Source: Mayo Clinic Proceedings, Jul 2008

  [ Not Yet Rated ]   [ Discuss This Article ]
By DJ Becker, et al. • www.ProHealth.com • July 18, 2008


[Note: Statins, such as simvastatin, are cholesterol-lowering prescription drugs.]

Objective: To compare the lipid-lowering effects of an alternative regimen (lifestyle changes, red yeast rice, and fish oil) with a standard dose of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin).

Patients and Methods: This randomized trial enrolled 74 patients with hypercholesterolemia [high cholesterol] who met Adult Treatment Panel III criteria for primary prevention using statin therapy.

All participants were randomized to an alternative treatment group (AG) or to receive simvastatin (40 mg/d) in this open-label trial conducted between April 1, 2006, and June 30, 2006.

The alternative treatment included:

  • Therapeutic lifestyle changes,
  • Ingestion of red yeast rice,
  • And fish oil supplements, for 12 weeks.
  • The simvastatin group received medication and traditional counseling.

    The primary outcome measure was the percentage change in low-density lipoprotein cholesterol (LDL-C)[referred to as 'bad' cholesterol]. Secondary measures were changes in other lipoproteins and weight loss.

    Results:

  • There was a statistically significant reduction in LDL-C levels in both the AG (-42.4%+/-15%) (P<.001) and the simvastatin group (-39.6%+/-20%) (P<.001).
  • No significant differences were noted between groups.
  • The alternative treatment group also demonstrated significant reductions in triglycerides (-29% vs -9.3%; 95% confidence interval, -61 to -11.7; P=.003) and weight (-5.5% vs -0.4%; 95% confidence interval, -5.5 to -3.4; P<.001) compared with the simvastatin group.
  • Conclusion: Lifestyle changes combined with ingestion of red yeast rice and fish oil reduced LDL-C in proportions similar to standard therapy with simvastatin.

    Pending confirmation in larger trials, this multifactorial, alternative approach to lipid lowering has promise for a subset of patients unwilling or unable to take statins.

    Source: Mayo Clinic Proceedings. Jul 2008;83(7):758-64. PMID: 18613992, by Becker DJ, Gordon RY, Morris PB, Yorko J, Gordon YJ, Li M, Iqbal N. Division of Cardiology, Chestnut Hill Hospital, University of Pennsylvania Health System, Philadelphia, PA, USA. [E-mail: dbeckerchcardiology@hotmail.com]





    Post a Comment

    Featured Products From the ProHealth Store
    Optimized Curcumin Longvida® Vitamin D3 Extreme™ FibroSleep™

    Looking for Vitamins, Herbs and Supplements?
    Search the ProHealth Store for Hundreds of Natural Health Products


    Article Comments



    Be the first to comment on this article!

    Post a Comment


     
    NAD+ Ignite with Niagen

    Featured Products

    Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
    Ultra concentrated source of essential fish oils
    Vitamin D3 Extreme™ Vitamin D3 Extreme™
    50,000 IU Vitamin D3 - Prescription Strength
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    Energy NADH™ 12.5mg Energy NADH™ 12.5mg
    Improve Energy & Cognitive Function

    Natural Remedies

    The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
    Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
    Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
    How Glutathione Can Save Your Life How Glutathione Can Save Your Life
    Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints

    CONTACT US
    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    SHOP WITH CONFIDENCE
    Credit Card Processing
    SUBSCRIBE TO OUR NEWSLETTERS
    Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map