To assess whether vitamin D supplementation in infancy reduces risk of type 1 diabetes in later life.
Design: Systematic review and meta-analysis.
Data Sources: Medline, Embase, Cinahl, Cochrane Central Register of Controlled Trials and reference lists of retrieved articles.
Main outcome measure: Development of type 1 diabetes.
Inclusion criteria: Controlled trials and observational studies which had assessed the effect of vitamin D supplementation on risk of developing type 1 diabetes.
Results: Five observational studies met the inclusion criteria; no randomised controlled trials were found. 4 of the 5 included studies were case control studies and the fifth study was a cohort study.
Meta-analysis of data from the case control studies showed that the risk of type 1 diabetes was significantly reduced in infants who were supplemented with vitamin D compared to those who were not supplemented (pooled odds ratio 0.71, 95% CI 0.60 to 0.84). The result of the cohort study was in agreement with that of the meta-analysis.
There was also some evidence of a dose-response effect, with those using higher amounts of vitamin D being at lower risk of developing type 1 diabetes.
Finally, there was a suggestion that the timing of supplementation might also be important for the subsequent development of type 1 diabetes.
Conclusion: Vitamin D supplementation in early childhood may offer protection against the development of type 1 diabetes.
The evidence for this is based on observational studies. Adequately powered, randomized controlled trials with long periods of follow-up are needed to establish causality and the best formulation, dose, duration and period of supplementation.
Source: Archives of Disease in Childhood, Mar 13, 2008. E-pub ahead of print. PMID: 1833965, by Zipitis CS, Akobeng AK. Central Manchester and Manchester Children's University Hospitals, UK. [E-mail: