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Expanding the spectrum of neurological disease associated with Epstein-Barr virus activity – Source: European Journal of Microbiology and Infectious Disease, May 15, 2011

  [ 25 votes ]   [ 1 Comment ]
By M Kleines, M Hausler, et al. • • May 22, 2011

The purpose of this study was to delineate the spectrum of neurological diseases attributed to Epstein-Barr virus (EBV) activity.

The approach was a retrospective study on patients with EBV activity proven by a positive EBV antibody-specific index (AI) and/or cerebrospinal fluid (CSF) PCR.

106 children and adults (AI positive=77, AI+PCR positive = 3, PCR positive=26) were identified, most with reactivated infections.

• 28 showed typical EBV-related diseases (encephalitis, neuritis, meningitis),

• 19 further infections (HSV encephalitis, neuroborreliosis, HIV infection, bacterial meningitis),

• 9 immune-mediated disorders (multiple sclerosis, optic neuritis),

• And 50 further diseases not typical for EBV.

The highest AI values occurred in patients with encephalitis.

No relationship between disease category or AI values and viral loads was found.

Additional reanalysis of 1,500 consecutive CSF EBV PCR studies revealed the highest positive rates among patients with further infections (n=18/227, 7.9%) but lower rates among patients with typical EBV-related disorders (5/395; 1.3%), immune-mediated disorders (n=2/174; 1.1%) and other conditions (n=4/704; 0.6%).

Intrathecal EBV activity [in the spinal canal/brain] is not restricted to typical EBV-related disorders, unexpectedly frequent in further CNS infections, and also present in non-inflammatory conditions.

Prospective studies should assess the pathogenic role of EBV in these different diseases.

Source: European Journal of Microbiology and Infectious Disease, May 15, 2011. PMID: 21573818, Kleines M, Schiefer J, Stienen A, Blaum M, Ritter K, Häusler M. Division of Virology / Dept. of Medical Microbiology, University Hospital, Aachen, Germany. [Email:]

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epstein barr virus complications
Posted by: tntboys
Aug 11, 2014
I lost my 17 year old son, Tyler Lane Budro, on March 10,2013 to an unknown illness. He was 17 years old and a junior at Hull Daisetta High School. He was sent home from school sick on Tuesday February 19 and went to the doctor that day. They did a mono test and gave him antibiotics. The next day he wasn't any better so he was taken to the doctor again. He received an antibiotic shot and more medicine. On the next day, Thursday, he felt better and ate really good. Friday, February 22, his girlfriend came to check on him and she left him at 1:45 and my dad came home at 4 and found him on the floor. He had been having seizures and was not responsive. He was taken to the ER in Beaumont, TX and was transferred to Pediatric ICU at Memorial Herman hospital in Houston. They were not able to stop him from having seizures and he was put into a medical induced coma to slow down brain activity. Most of his skull was removed to allow room for his brain to swell. They ran test after test to try and find out what was wrong with him, but the only thing he ever tested positive for was mono. After 16 days in ICU we lost him on March 10, 2013, the day before his brothers 16th birthday. It took 10 months before the autopsy was completed and another month to get the report, but they still didn't find anything.
I was just wondering if his case is one that you would want to use in your research. If you are interested, I would be happy for you to. If one person can be saved from having to go through what he went through and the family also, it would mean so much to me.
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