ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

Ginger Fights Obesity

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Eating more vegetable protein may protect against early menopause

Is Activated Charcoal Beneficial?

 
Print Page
Email Article

Restless Legs Syndrome is associated with Irritable Bowel Syndrome and Small Intestinal Bacterial Overgrowth – Source: Sleep Medicine, May 12, 2011

  [ 11 votes ]   [ 1 Comment ]
By Leonard B Weinstock, Arthur S Walters • www.ProHealth.com • June 1, 2011


[Note: SIBO is a condition where abnormally large numbers of bacteria are present in the small intestine where nutrient absorption takes place, and these bacteria are the types typically found downstream in the colon.]

Background: Restless legs syndrome (RLS) is linked to gastrointestinal disorders. The prevalence of irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO) in RLS patients was determined.

Methods: RLS subjects were recruited from unbiased ads that did not mention gastrointestinal symptoms. RLS diagnosis was confirmed by a neurologist and utilized the International RLS Study Group criteria.

General population controls (GPC) were spouses of gastrointestinal clinic patients and were excluded for RLS.

Completely healthy controls (CHC) were excluded for RLS and gastrointestinal symptoms.

IBS was diagnosed by Rome II criteria. SIBO was diagnosed by the lactulose breath test (LBT).

Results: There were 32 RLS subjects (23F/9M; 57 yo), 25 GPC (13F/12M; 58 yo) and 30 CHC (19F/11M; 44 yo). Twenty-nine had RLS unassociated with other GI diseases, one had celiac disease, and two had gastric resections.

• IBS was diagnosed in 28% of RLS subjects compared to 4% of general population controls (p=0.0317).

• SIBO was diagnosed in 69% of RLS subjects compared to 28% of general population controls (p=0.0033) and 10% of completely healthy controls. Using a false positive rate of 10%, 59% of positive lactulose breath test results are associated with RLS.

Conclusions: IBS and SIBO are common in RLS. Three hypotheses developed are:

a. RLS patients are selectively immunocompromised or genetically predisposed and thus more subject to SIBO;

b. Small intestinal bacterial overgrowth leads to autoimmune changes, and subsequent auto-antibodies attack brain and/or peripheral nerves, and

c. Small intestinal bacterial overgrowth inflammation leads to increased hepcidin and CNS iron deficiency which, in turn, leads to RLS.

These hypotheses bear further investigation.

Source: Sleep Medicine, May 12, 2011. PMID: 21570907, by Weinstock LB, Walters AS. Department of Internal Medicine, Washington University School of Medicine and Specialists in Gastroenterology, LLC, St. Louis, Missouri; Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. [Email: lw@gidoctor.net]





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

IBS and SIBO aggravate leaky gut
Posted by: IanH
Jun 2, 2011
With Small intestinal bacterial overgrowth the bi-products of digestion can leak through the gut wall. There is some evidence that such "leakage" is a cause of some of the neurological symptoms in FMS and ME/CFS (as well as MCS). This syndrome can be reduced by taking 5 grams Bovine Colostrum (in 100 mls water) twice daily before meals. Colostrum has been shown to reduce leaky gut. When taken with an appropriate pro-biotic the symptoms, including restless legs syndrome can be markedly reduced. The colostrum takes about 3 weeks to have noticeable effect. For some people the addition of zinc facilitates the benefit.
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map