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Postural Orthostatic Tachycardia Syndrome following Lyme disease – Source: Journal of Cardiology, Issue #2, 2011

  [ 23 votes ]   [ 5 Comments ]
By K Kanjwal, BP Grubb, et al. • • June 4, 2011

[Note: The symptoms of these patients with POTS (suggesting "post treatment Lyme disease syndrome") were helped significantly by drugs typically prescribed for orthostatic dysfunction. To read the full text pdf of this article click HERE ]

Background: A subgroup of patients suffering from Lyme disease (LD) may initially respond to antibiotics only to later develop a syndrome of fatigue, joint pain and cognitive dysfunction referred to as 'post treatment LD syndrome'. We report on a series of patients who developed autonomic dysfunction in the form of postural orthostatic tachycardia syndrome (POTS).

All of the patients in this report had suffered from LD in the past and were successfully treated with antibiotics. All patients were apparently well, until years later when they presented with fatigue, cognitive dysfunction and orthostatic intolerance. These patients were diagnosed with POTS on the basis of clinical features and results of the tilt table (HUTT) testing.


• Five patients (all women), aged 22-44 years, were identified for inclusion in this study. These patients developed symptoms of fatigue, cognitive dysfunction, orthostatic palpitations and either near syncope or frank syncope [faintness on rising to upright position/standing].

• The debilitating nature of these symptoms had resulted in loss of employment or inability to attend school.

• Three patients were also suffering from migraine, two from anxiety and depression and one from hypertension.

• All patients demonstrated a good response to the employed treatment.

• Four of the five were able to engage in their activities of daily living and either resumed employment or returned to school.

Conclusions: In an appropriate clinical setting, evaluation for POTS in patients suffering from post LD syndrome may lead to early recognition and treatment, with subsequent improvement in symptoms of orthostatic intolerance.

Source: Journal of Cardiology, 2011; vol 18(1):63-6. PMID: 21305487, by Kanjwal K, Karabin B, Kanjwal Y, Grubb BP. Section of Electrophysiology, Division of Cardiology, Department of Medicine,The University of Toledo Medical Center, Toledo, USA. [Email:]

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Article Comments Post a Comment

Posted by: lymeoneofakind
Jun 6, 2011
I have over 230 scientific references on the persistnce of the Borrelia bacteria within the human body despite antibiotic treatment. Testing is inaccurate - so how do "they" really know the "treatment was successful"? Current treatment guidelines are faulty and not long enough to eradicate this most genius bacteria - this bacteria "hides" when threatened - has 3 forms - spirochetal, cell wall deficient and cyst form. It is very likely that the "syndromes" being refered to here are actually signs of persistent infection. People have actually died following unsuccessful treatment that is based on the current treatment guidelines - died from numerous issues...including heart. Time to wake up and realize that the guidelines are faulty - treatment based on these guidelines does not work for most people and damage is still being done by the bacteria after it comes out of "hiding". It lives in connective tissues, organs and can even drill into bone - is very hard to detect antibodies in blood because of this fact AND the fact that there are hundreds of borrelia species (which have a 25 chain DNA)and the current testing only looks for a few of these species...gee, don't even get me started on the co-infections one can aquire along with the Borrelia.
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persistence of Lyme pathogen
Posted by: artifact
Jun 8, 2011
I have studied this extensively myself, and fully agree with the previous post. Borrelia spp (Lyme Disease pathogen) cannot be successfully eradicated from the human body with any known medical treatment, except for infections that are treated adequately with antibiotics in the first ~ 4 weeks of infection. Once the Lyme pathogen completes a life cycle (4 wks) and some of them go into cyst stage, the best that can be hoped for is remission, which is to say that the body's immune system becomes able to keep Borrelia at bay, after the population of this bacteria is knocked down by antibiotics, stress reduction, etc.
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further reading
Posted by: artifact
Jun 8, 2011
Pamela Weintraub's book, 'Cure Unknown.' Exhaustively researched and referenced. Splendidly written by a top-notch science journalist.

The film documentary 'Under Our Skin' also.

Dr. Joe Burrascano's 2008 Treatment Guidelines.


further reading
Posted by: artifact
Jun 8, 2011
Pamela Weintraub's book, 'Cure Unknown.' Exhaustively researched and referenced. Splendidly written by a top-notch science journalist.

The film documentary 'Under Our Skin' also.

Dr. Joe Burrascano's 2008 Treatment Guidelines.


Look to the source
Posted by: RAJOD
Aug 2, 2011
This assumption was not verified. "All of the patients in this report had suffered from LD in the past and were successfully treated with antibiotics." Recently borrelilia have been found hiding in (of all places) the lymph glands. The seem to invoke an immune response that while strong is ineffective in totally erraticating the organism. Because of their specialty they are study but one of many symptoms. Rather than do this they out to be investigating the source. Start asking simple questions like "why would they have anxiety?, what physical change brought on these symptoms. Brain Pet scans can be revealing, showing areas of low perfusion. Most likely it is the return of the organism. The symptoms most likely from inflammatory damage to the CNS. Biopsies of lymph glands and other areas might reveal the true source. Rather than treating symptoms they should be looking to the source.
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