ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

Curcumin Reverses the Cellular Damage of Chronic Stress

 
Print Page
Email Article

Human Vaccine Cures Prostate Cancer in Mayo Pilot Animal Trial

  [ 11 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 20, 2011


Vaccine cells made from bits of healthy prostate tissue DNA attack only cancerous cells, leaving healthy tissue unharmed. Human trials “within two years.”

Mayo Clinic investigators and collaborators from the UK cured well-established prostate tumors in mice using a human vaccine with no apparent side effects, as reported June 19 in Nature Medicine.

• This novel cancer treatment approach encourages the immune system to rid itself of prostate tumors without assistance from toxic chemotherapies and radiation treatments.

• Such a treatment model could some day help people to live tumor free with fewer side effects than those experienced from current therapies.

"We are hopeful that this will overcome some of the major hurdles which we have seen with immunotherapy cancer research," says Mayo Clinic immunologist Richard Vile, PhD, a lead author of the study.

(Mayo reportedly sees more prostate cancer patients than any other medical center in the world, and its Cancer Center is a leader in translation of biological research to improved methods of prevention, detection, and treatment.)

Mayo's immunotherapy research, led by Dr. Vile:

• Already shows promise in treating prostate cancer and melanoma.

• And is a prime candidate for treatment of many more aggressive cancers, such as lung, brain and pancreatic cancer.

Among the team's findings: no trace of autoimmune diseases in the mice. The murine T-cells attacked only cancerous prostate cells, leaving the healthy tissue unharmed.

To develop this new approach:

• Geneticists assembled snippets of genetic code from healthy human prostate tissue into a complementary DNA (cDNA) library.

• These bits of cDNA were then inserted into a swarm of vesicular stomatitis viruses (VSV),

• Which were cultured and reintroduced into the test mice as a vaccine during a series of intravenous injections.

Development of comprehensive cDNA libraries from healthy human prostate tissue represents the key to successful immunotherapy.

All infections, allergens and tissues, including tumors, have a unique fingerprint called an antigen - a molecular protein tag that triggers a response from the body's immune system.

Dr. Vile deployed the human vaccine prostate cancer antigens through the mutated VSV vector to raise a full-on assault from the mice's T-cells. After exposure to the mutated viruses, the animals' immune systems recognized the antigens expressed in the virus and produced a potent immune response to attack the prostate tumors.

"Nobody really knows how many antigens the immune system can really see on tumor cells," says Dr. Vile.

• "By expressing all of these proteins in highly immunogenic viruses, we increased their visibility to the immune system.

• “The immune system now thinks it is being invaded by the viruses, which are expressing cancer-related antigens that should be eliminated."

Previous attempts to vaccinate against prostate and other types of cancerous tumors have been hampered largely by researchers' inability to isolate a sufficiently diverse and robust collection of antigens in tumor cells. Because of this, tumors often mutate and re-establish themselves in spite of the body's immune system.

The use of viruses as vectors for cDNA libraries overcomes the difficulty of isolating antigens in tumor cells by giving the immune system a more complete picture of the cancerous invader.

This study was a Mayo collaboration with Alan Melcher, PhD, and Peter Selby, PhD, both from the Cancer Research UK Clinical Centre at St. James' University Hospital and professors at the Leeds Institute of Molecular Medicine, University of Leeds, UK….

The study was funded by the National Institutes of Health, Cancer Research UK, The Richard M. Schulze Family Foundation, the Mayo Clinic, and a private grant.

Source: Mayo Clinic (Rochester, MN) news release and website, Jun 19, 2011




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map