ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

Will Gene Variant Discovery Explain Fibromyalgia?

  [ 44 votes ]   [ Post a Comment ]
www.ProHealth.com • June 17, 2011

previous article next article

The whole-genome sequencing of 14-year-old California twins with a mystery illness, and of their parents, brother, and grandparents, produced an important discovery with potentially far-reaching implications.

As reported June 15 in Science Translational Medicine(1) and by the National Public Radio Health Blog(2), the twins had a condition termed "DRD" (dopa-responsive dystonia), meaning they had "cerebral palsy-like" spasms thought to result from a deficiency of the neurotransmitter dopamine, which was helped by low doses of the Parkinson’s disease drug L-dopa.

The family’s whole-genome sequencing indicated that the twins had received a double dose of a gene variant (mutation) – one from their father's side, and one from their mother's side – that caused them to have low levels not just of dopamine but of the neurotransmitters serotonin and noradrenalin.

When their neurologist at Children’s Hospital in San Diego decided that in addition to L-dopa they should try supplementing the twins with 5-HTP (5-Hydroxy L-Tryptophan, a precursor that the body uses in serotonin production) their physical condition improved to a remarkable degree. 

Where Does Fibromyalgia Come In?
 
It turns out that there is a pattern of known fibromyalgia symptoms in the mother’s family (FM affects predominantly females), which could well be linked to the single copy of the gene variant that they carry. The researchers hypothesize that this gene variant could help explain the positive response of some fibromyalgia patients to SSRI anti-depressants, which work by raising serotonin levels.

“If that hypothesis pans out,” the NPR blog comments, “it would suggest that rare genetic disorders such as DRD are just the most dramatic manifestation – in people who inherit a double dose of certain gene variants – of much more common disorders such as fibromyalgia among people who have a single copy of the mutation.”

Discovery Was a Lucky Break

The twins’ father works for a biotech company that makes DNA sequencing machines, and was able to convince the pioneering researchers in whole-genome sequencing at Baylor College of Medicine to take on the family genome-sequencing project.

So is it only a matter of time before they or other cutting edge gene hunters will mount further studies of this potential “fibromyalgia variant” to see what it might reveal?

______

Sources:

1. “Whole-Genome Sequencing for Optimized Patient Management,” Matthew Banibridge, et al. Science Translational Medicine, June 15, 2011

2. “Genome Maps Solve Medical Mystery for California Twins,” by Richard Knox. NPR Health Blog, June 16, 2011


previous article
  Rating 4.3 (44 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
OsteoTec™ UC-II® OsteoTec™ UC-II®
A True Breakthrough in Joint health
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

Massage Therapy Studies for Fibromyalgia Reviewed [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Breaking News: FDA’s Sneak Attempt to Ban Another B Vitamin [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

FDA Says Sponsors of Chronic Fatigue Syndrome Drugs can Rely on Patient-Reported Outcomes [more]

Sensory Overload: Sources and Strategies [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing