ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Lutein — An Important Nutrient for Eye and Brain Health

Hop Oil: A Safe Sleep Aide

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

 
Print Page
Email Article

Gene Mutation Causing Hyper-excitable Nerve Cells Explains Many Cases of 'Unexplained Pain' - Yale

  [ 16 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 25, 2011


Mutations in the SCN9A gene (found in a third of ‘unexplained’ neuropathic pain patients) cause nerve cells to be hyper-excitable, thus leading to degeneration of the nerve fibers.

Roughly 20 million people in the US suffer from peripheral neuropathy, marked by the degeneration of nerves and in some cases severe chronic pain. There is no good treatment for the disorder and no apparent cause for the destruction in a third of cases.

But now an international team of scientists headed by researchers from Yale University and the Veterans Affairs Medical Center in New Haven, Connecticut, and the University Maastricht in the Netherlands have linked mutations of a single gene to 30% of cases of unexplained neuropathy.

The findings, published online June 22 in the Annals of Neurology, could lead to desperately needed pain treatments for many victims of this debilitating disorder.

"For millions of people, the origin of this intense pain has been a frustrating mystery," says Yale neurologist Stephen Waxman, MD, a co-author of the study. "All of us were surprised to find that these mutations occur in so many patients with neuropathy with unknown cause."

The study focused on mutations of a single gene - SCNA9 - which is expressed in sensory nerve fibers.

• Waxman's group had discovered that mutations in this gene's product - the protein sodium channel Nav1.7 - cause a rare disorder called "Man on Fire Syndrome," characterized by excruciating and unrelenting pain.

• Colleagues in the Netherlands carefully scrutinized neuropathy patients to rule out all known causes of the neuropathy, such as diabetes, alcoholism, metabolic disorders and exposure to toxins.

• Researchers then did a genetic analysis of 28 patients with neuropathy with no known cause. They found that:

- 30% of these subjects had mutations in the SCN9A gene.

- And the mutations cause nerve cells to become hyperactive, a change they believe eventually leads to degeneration of nerve fibers.

"These findings will help us as clinicians to a better understanding of our patients with small fiber neuropathy and could ideally have implications for the development of future specific therapies," says University Maastrict co-author Catharina G. Faber, MD, PhD.

The research was funded by the Department of Veterans Affairs, The Erythromelalgia Association (USA), and the Profileringsfonds of University of Maastricht, The Netherlands.

Source: Yale University news release, Jun 22, 2011




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
How One Tiny Molecule Turned into One Huge Health Breakthrough How One Tiny Molecule Turned into One Huge Health Breakthrough
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
How Glutathione Can Save Your Life How Glutathione Can Save Your Life

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map