ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Gene Mutation Causing Hyper-excitable Nerve Cells Explains Many Cases of 'Unexplained Pain' - Yale

  [ 16 votes ]   [ Discuss This Article ] • June 25, 2011

Mutations in the SCN9A gene (found in a third of ‘unexplained’ neuropathic pain patients) cause nerve cells to be hyper-excitable, thus leading to degeneration of the nerve fibers.

Roughly 20 million people in the US suffer from peripheral neuropathy, marked by the degeneration of nerves and in some cases severe chronic pain. There is no good treatment for the disorder and no apparent cause for the destruction in a third of cases.

But now an international team of scientists headed by researchers from Yale University and the Veterans Affairs Medical Center in New Haven, Connecticut, and the University Maastricht in the Netherlands have linked mutations of a single gene to 30% of cases of unexplained neuropathy.

The findings, published online June 22 in the Annals of Neurology, could lead to desperately needed pain treatments for many victims of this debilitating disorder.

"For millions of people, the origin of this intense pain has been a frustrating mystery," says Yale neurologist Stephen Waxman, MD, a co-author of the study. "All of us were surprised to find that these mutations occur in so many patients with neuropathy with unknown cause."

The study focused on mutations of a single gene - SCNA9 - which is expressed in sensory nerve fibers.

• Waxman's group had discovered that mutations in this gene's product - the protein sodium channel Nav1.7 - cause a rare disorder called "Man on Fire Syndrome," characterized by excruciating and unrelenting pain.

• Colleagues in the Netherlands carefully scrutinized neuropathy patients to rule out all known causes of the neuropathy, such as diabetes, alcoholism, metabolic disorders and exposure to toxins.

• Researchers then did a genetic analysis of 28 patients with neuropathy with no known cause. They found that:

- 30% of these subjects had mutations in the SCN9A gene.

- And the mutations cause nerve cells to become hyperactive, a change they believe eventually leads to degeneration of nerve fibers.

"These findings will help us as clinicians to a better understanding of our patients with small fiber neuropathy and could ideally have implications for the development of future specific therapies," says University Maastrict co-author Catharina G. Faber, MD, PhD.

The research was funded by the Department of Veterans Affairs, The Erythromelalgia Association (USA), and the Profileringsfonds of University of Maastricht, The Netherlands.

Source: Yale University news release, Jun 22, 2011

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Optimized Curcumin Longvida® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map