ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

On-and-off fasting helps fight obesity, study finds

Can Pomegranates Slow Aging?

Calorie restriction promotes longevity through effects on mitochondrial network

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

A spoonful of oil: Fats and oils help to unlock full nutritional benefits of veggies, study suggests

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

How Can You Benefit From Vitamin B12?

Drug can dramatically reduce weight of people with obesity

What Is Bitter Orange?

 
Print Page
Email Article

Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: A case control study – Source: European Journal of Clinical Investigation, online June 10, 2011

  [ 3 votes ]   [ Discuss This Article ]
By David EJ Jones, Julia L Newton, et al. • www.ProHealth.com • June 30, 2011


Background: Chronic fatigue syndrome (CFS) patients frequently describe difficulties with repeat exercise. Here we explore muscle bioenergetic function in response to 3 bouts of exercise.

Methods: 18 CFS (CDC 1994) patients and 12 sedentary controls underwent assessment of maximal voluntary contraction (MVC), repeat exercise with magnetic resonance spectroscopy and cardio-respiratory fitness test to determine anaerobic threshold.

[Note: Reaching the "anaerobic threshold" during exercise is when muscles switch from "aerobic" production of cellular fuel (ATP), using oxygen & glucose, to producing ATP "anaerobically" using stored phosphocreatine (PCr) without oxygen. That is, when there's a lack of sufficient oxygen supply in the working muscle cells and carbon dioxide production is increased, generating lactic acid. PCr stores are depleted fairly quickly, and normally PCr is regenerated/lactic acid is dispersed when aerobic exercise can resume/muscles are at rest.]

Results: CFS patients undertaking MVC fell into 2 distinct groups.

• 8 (45%) showed normal PCr depletion in response to exercise at 35% of MVC (PCr depletion > 33%; lower 95% CI for controls).

• 10 CFS patients (55%) had low PCr depletion (generating abnormally low MVC values).

The CFS whole group exhibited significantly reduced anaerobic threshold, heart rate, VO2, VO2 peak and peak work compared to controls. [VO2 peak is the maximum ability to take up oxygen for ATP creation.]

Resting muscle pH [measure of acidity/alkalinity] was similar in controls and both CFS patient groups.

However, the CFS group achieving normal PCr depletion values showed increased intra-muscular acidosis compared to controls after similar work after each of the 3 exercise periods with no apparent reduction in acidosis with repeat exercise of the type reported in normal subjects.

This CFS group also exhibited significant prolongation (almost 4-fold) of the time taken for pH to recover to baseline.

Conclusion: When exercising to comparable levels to normal controls, CFS patients exhibit profound abnormality in bioenergetic function and response to it.

Although exercise intervention is the logical treatment for patients showing acidosis, any trial must exclude subjects who do not initiate exercise, as they will not benefit.

This potentially explains previous mixed results in CFS exercise trials.

Source: European Journal of Clinical Investigation, online June 10, 2011. DOI:10.1111/j.1365-2362.2011.02567.x, by Jones DEJ, Hollingsworth Kg, Jokovljevic DG, Fattakhova G, Pairman J, Blamire AM, Trenell MI, Newton JL. Institute of Cellular Medicine; Newcastle Magnetic Resonance Centre; Institute for Ageing and Health; the UK NIHR Biomedical Research Centre in Ageing and Age Related Diseases; Newcastle Centre for Brain Ageing and Vitality, Newcastle University, Newcastle-upon-Tyne, UK.[Email: j.l.newton@ncl.ac.uk]





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® FibroSleep™ Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Break Free From Fibromyalgia Break Free From Fibromyalgia
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Breaking Through the Mental Fog Breaking Through the Mental Fog

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map