ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Mediterranean diet associated with lower risk of aggressive prostate cancer

Vitamin D3 Is a Powerhouse for Your Heart

 
Print Page
Email Article

More evidence fish oil DHA may support brain vs. ischemic stroke damage

  [ 26 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 1, 2011


Article:
Accumulation of Dietary Docosahexaenoic Acid in the Brain Attenuates Acute Immune Response and Development of Postischemic Neuronal Damage – Source: Stroke, Aug 18, 2011

By Hebert M Lalancette, et al.

[Note: Ischemic stroke involves blockage that interrupts blood supply to part of the brain. For more recent research on this subject, see “Fish oil DHA within 5 hours after stroke may limit & even repair some brain damage - LSU research discovery.”]

Background and Purpose: Consumption of fish has been shown to reduce risk of coronary heart disease and, possibly, of ischemic stroke.

Because docosahexaenoic acid (DHA) is the most likely neuroactive component within fish oil, we hypothesized that exposing mice to a DHA-enriched diet may reduce inflammation and protect neurons against ischemic injury.

Methods: To visualize the effects of DHA on neuroinflammation after stroke, TLR2-fluc-GFP transgenic mice were exposed to either a control diet, a diet depleted in omega-3 polyunsaturated fatty acid, or a diet enriched in DHA during 3 months.

Real-time biophotonic/bioluminescence imaging of the TLR2 response was performed before and after middle cerebral artery occlusion, whereas cytokines concentrations and stroke area analyses were performed at 3 and 7 days after middle cerebral artery occlusion, respectively.

Results: We show that:

• A 3-month DHA treatment prevented microglial activation after ischemic injury, [microglia are thought to contribute to ischemic stroke damage by inducing inflammatory response]

• Reduced the ischemic lesion [damage] size,

• And increased levels of the antiapoptotic molecule Bcl-2 in the brain [apoptosis is cell death].

• Additional analysis revealed a significant decrease in the levels of COX2 and IL-1beta, but not in other proinflammatory cytokines.

• Importantly, long-term DHA supplementation significantly changed the omega-3 to omega-6 polyunsaturated fatty acid ratio in the brain [an imbalance toward too much omega-6 is considered proinflammatory].

Conclusions:

• Collectively, these data indicate that diet-induced accumulation of DHA in the brain protects against post-ischemic inflammation and injury.

• Because DHA is widely available at low cost and has an excellent safety profile, our data suggest that increased DHA intake may provide protection against acute immune response/brain damage in ischemic stroke.

Source: Stroke, Aug 18, 2011. PMID: 21852616, by  Lalancette-Hébert M, Julien C, Cordeau P, Bohacek I, Weng YC, Calon F, Kriz J. Croatian Institute for Brain Research, Zagreb University Medical School, Zagreb, Croatia; Department of Psychiatry and Neuroscience, Faculty of Medicine, Faculty of Pharmacy, Université Laval, Laval University, CHUQ Research Center-Laval University, Québec, Canada. [Email: jasna.kriz@crchul.ulaval.ca]





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map