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Get cross when you’re hungry? Tryptophan depletion is to blame

  [ 26 votes ]   [ Discuss This Article ] • September 16, 2011

The first study to explain how a lack of dietary tryptophan deprives the brain of serotonin, causing temper-controlling connections to 'short out'. And why some people are more affected than others.

Fluctuations of serotonin levels in the brain - which often occur when someone hasn’t eaten or is stressed - affect brain regions that enable people to regulate anger, new research from the University of Cambridge has shown.

Although reduced serotonin levels have previously been implicated in aggression, this is the first study which has identified:

• How this chemical helps regulate behavior in the brain

• As well as why some individuals may be more prone to aggression.

For the study, published Sep 15 by Biological Psychiatry,(1) healthy volunteers’ serotonin levels were altered by manipulating their diet:

• On the serotonin depletion day, they were given a mixture of amino acids that lacked tryptophan, the building block for serotonin. (Most animal and plant foods contain tryptophan, aka L-tryptophan.)

• On the placebo day, they were given the same mixture but with a normal amount of tryptophan.

The researchers then scanned the volunteers’ brains using functional magnetic resonance imaging (fMRI) as they viewed faces with angry, sad, and neutral expressions.

Using the fMRI, they were able to measure how different brain regions reacted and communicated with one another when the volunteers viewed angry faces, as opposed to sad or neutral faces.

The research revealed that:

• Low brain serotonin made communications between specific brain regions of the emotional limbic system of the brain (a structure called the amygdala) and the frontal lobes weaker compared to those present under normal levels of serotonin.

• The findings suggest that when serotonin levels are low, it may be more difficult for the prefrontal cortex to control emotional responses to anger that are generated within the amygdala.

Using a personality questionnaire, they also determined which individuals have a natural tendency to behave aggressively.

• In these individuals, the communication between the amygdala and the prefrontal cortex was even weaker following serotonin depletion.

• ‘Weak’ communications means that it is more difficult for the prefrontal cortex to control the feelings of anger that are generated within the amygdala when the levels of serotonin are low

As a result, those individuals who might be predisposed to aggression were the most sensitive to changes in serotonin depletion.

“We’ve known for decades that serotonin plays a key role in aggression, but it’s only very recently that we’ve had the technology to look into the brain and examine just how serotonin helps us regulate our emotional impulses," says co-first author Molly Crockett, PhD. “By combining a long tradition in behavioral research with new technology, we were finally able to uncover a mechanism for how serotonin might influence aggression.”

“Although these results came from healthy volunteers, they are also relevant for a broad range of psychiatric disorders in which violence is a common problem,” adds co-first author Luca Passamonti, PhD. “For example, these results may help to explain the brain mechanisms of a psychiatric disorder known as intermittent explosive disorder (IED). Individuals with IED typically show intense, extreme and uncontrollable outbursts of violence which may be triggered by cues of provocation such as a facial expression of anger.

“We are hopeful that our research will lead to improved diagnostics as well as better treatments for this and other conditions.”


1. Article: “Effects of Acute Tryptophan Depletion on Prefrontal-Amygdala Connectivity while Viewing Facial Signals of Aggression,” Passamonti L, Crockett MJ, et al.

Source: University of Cambridge news release, Sep 15, 2011

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