ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Trimming the spare tire: Canola oil may cut belly fat

 
Print Page
Email Article

Investigational Drug Effective and Well-Tolerated For Osteoarthritis Pain

  [ 2 votes ]   [ 8 Comments ]
By News Release • www.ProHealth.com • January 23, 2000


BOSTON, MA -- An investigational medicine being developed by Merck & Co., Inc. significantly relieved more pain in patients with osteoarthritis of the knee than did placebo, according to a dose-ranging study presented by researchers at the annual meeting of the American College of Rheumatology.

"Patients treated with MK-663 had less walking pain or pain going up or down stairs or were awakened at night by pain less often than patients on placebo," says Dr. Thomas J. Schnitzer, professor and director, office of Clinical Research and Training, Northwestern University and a study investigator. "We also saw that patients on MK-663 had less difficulty doing simple everyday activities, such as getting out of bed, bending down to hug a child, getting in and out of a car, going grocery shopping, or dressing." MK-663 is an investigational medicine being developed by Merck that is designed to specifically inhibit the cyclooxygenase-2 (COX-2) enzyme.

In the multi-center, six-week study, 617 patients with osteoarthritis of the knee were randomized to MK-663 at 5 mg (117 patients), 10 mg (114 patients), 30 mg (102 patients), 60 mg (112 patients), 90 mg (112 patents) or placebo (60 patients) given once a day, after experiencing pain flare-up following withdrawal from treatment with non-steroidal anti-inflammatory drugs (NSAIDs). Efficacy and tolerability of MK-663 were evaluated at one, two, four and six weeks of therapy. At all doses studied, patients on MK-663 reported less pain compared to placebo (measured by the Western Ontario McMaster Osteoarthritis Questionnaire -- WOMAC), a validated measure of osteoarthritis symptoms).
Specific improvements with MK-663 included:
-- relief of pain including walking, stair climbing and night pain (WOMAC Questions 1-5, VAS, 0-100 mm);
-- overall patient assessment of response to therapy (Likert scale, 0-4 or "none" to "excellent"); and
-- physician's assessment of the patient's disease status (Likert scale).
Pain relief was measurable within the first week of treatment with MK-663, and sustained through the six-week study period. A dose response was observed. The 30 mg dose was superior to 5 mg and 10 mg. The 30 mg dose showed about half the effect of the 60 mg and 90 mg doses. The effect of those doses were similar.

Treatment with MK-663 was generally well-tolerated across the entire dose range in the study. The most commonly reported side effects for both MK-663 and placebo were diarrhea, nausea and headache. Few patients discontinued due to adverse events.

COX-2 triggers pain and inflammation, while another related enzyme, COX-1, helps maintain the normal stomach lining. Non-selective NSAIDs inhibit both COX-1 and COX-2, which can result in serious gastrointestinal side effects. In laboratory and clinical studies, MK-663 at doses up to 150 mg did not inhibit the COX-1 enzyme while significantly inhibiting the COX-2 enzyme.

Source: Merck & Co., Inc.



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Vitamin D3 Extreme™


Article Comments Post a Comment

test
Posted by: Holly-Admin
Apr 20, 2012
test

test 2

test 3
Reply Reply

 
Link
Posted by: Holly-Admin
Apr 20, 2012
Link

line 2

line 3

 

 
Test Link
Posted by: Holly-Admin
Apr 20, 2012
Test Link

skldfjsldjf

sdfjsl

 

 
Link
Posted by: Holly-Admin
Apr 20, 2012
Link

line 2

line 3

 

 
Test Link
Posted by: Holly-Admin
Apr 20, 2012
Test Link

skldfjsldjf

sdfjsl

 


Link
Posted by: Holly-Admin
Apr 20, 2012
Link here

skldfjlsdkjf

sdfjklsfkj
Reply Reply

lskdjfsdlj
Posted by: Holly-Admin
Apr 20, 2012
lkjdflj
Reply Reply

 
Link
Posted by: Holly-Admin
Apr 20, 2012
Link
skdfjlsf

lskdfjlsdfj

slkdjflsdfj

 



Post a Comment

 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map