ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

7 Best Foods You Can Eat

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

The Gut Microbiome and the Brain

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CoQ10 supplementation reduces statin-related muscle pain in randomized trial

Controlling obesity with potato extract

Plant used in traditional Chinese medicine may treat metabolic diseases and obesity

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections

Proton pump inhibitors decrease diversity in gut microbiome, increase risk for complications

 
Print Page
Email Article

Dopamine-Preserving Peptide Stops Parkinson’s Nerve Damage in Preclinical Trials

  [ 105 votes ]   [ 1 Comment ]
www.ProHealth.com • May 3, 2012


Parkinson's (the Michael J. Fox disease) is a progressive disorder that involves gradual die-off of nerve cells that produce dopamine, with resulting deterioration of cognition and movement. Though we naturally lose dopamine-producing neurons with age, Parkinson's accelerates the process and involves much more drastic deficiencies.

Readers diagnosed with fibromyalgia and chronic fatigue syndrome will note that dysfunctional dopamine production has also long been implicated in their illnesses as well - with the latest ME/CFS research suggesting it is at the root of underperforming nerve clusters in the brain.(1,2,3)

But now researchers at Tel Aviv University (TAU) report they’ve developed a peptide that can preserve dopamine and stop the neuron killing – actually stop it cold.

They’ve also found that the peptide can be injected effectively or even absorbed through the skin, and have developed an adhesive patch for sustained transdermal delivery.

The team at TAU began with a study of mutations in a gene known as DJ-1 that are associated with accelerated loss of dopaminergic neurons and onset of Parkinson’s symptoms at a young age. Normally, DJ-1 protects cells from toxic stresses,(4) and mutation-associated loss of that protection is associated with neuronal death. 

In hopes that “the ability to modify the activity of DJ-1 could change the progress of the disease,” the team set out to develop a peptide that mimics DJ-1's normal function so as to protect dopamine-producing neurons, explains principal investigator Nirit Lev, a movement disorders specialist at Tel Aviv University's Sackler Faculty of Medicine.

As they have recounted in the Journal of Neural Transmission and other journals, Dr. Nev and colleagues Dani Offen & Eldad Melamed explain that, using a short peptide based on the healthy version of DJ-1 itself as a vehicle, they:

• "Attached the DJ-1 related peptide to another peptide that would allow it to enter the cells, and be carried to the brain."

• Tested the treatment on mice utilizing well-established toxic and genetic models for Parkinson's disease.

• Discovered that, from both a behavioral and biochemical standpoint, the mice that received the peptide treatment showed remarkable improvement. Specifically:

- Symptoms such as mobility dysfunctions were reduced significantly,

- While dopamine-producing neurons were preserved and dopamine levels were increased in the brain.

Though many peptides have a short life span and degrade quickly, the researchers note that this peptide does not. Additionally, it provides a safe treatment option because peptides are organic to the body itself.

Overall, based on preclinical trials and hopefully human trials soon, their peptide treatment:

1. Mimics DJ-1's normal function of protecting neurons

2. Stops neurodegeneration and supports higher dopamine levels in the brain.

3. Reduces problems with mobility in preclinical trials.

4. Could be developed as a preventive strategy that “can mean the difference between living life as a Parkinson’s patient or aging normally.”

5. May hold special promise for those with a genetic link to the disease who might opt for early testing, now that with the help of brain scans Parkinson’s may sometimes be diagnosed before motor symptoms begin.

_____

Source: Based on American Friends Tel Aviv University news release, May 2, 2012

Citations:
1. “ME/CFS Appears to Be a Disease Affecting the Basal Ganglia & Dopamine Metabolism.”)

2. “Fibromyalgia study links level of dopamine metabolism & gray matter density in certain brain areas.”

3. “An Elephant Among Us: The Role of Dopamine in the Pathophysiology of Fibromyalgia,”  by Patrick B Wood, MD, and Andrew J Holman, MD. Journal of Rheumatology 36(2). Full text article, links to 33 other studies providing findings relevant to their theory.

4. "DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2"



Please Discuss This Article:   Post a Comment 

Tel aviv research Parkington's disease
Posted by: buckyball
May 9, 2012
this very meaningful please keep us in formed as to whether they need human guinea pigs to take the reseach for mice to product. Ron a Parkington sufferer
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Preserving Cognitive Function with Aging Preserving Cognitive Function with Aging

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing