ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

7 Best Foods You Can Eat

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

The Gut Microbiome and the Brain

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CoQ10 supplementation reduces statin-related muscle pain in randomized trial

Plant used in traditional Chinese medicine may treat metabolic diseases and obesity

Controlling obesity with potato extract

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections

 
Print Page
Email Article

Neurological effects of dietary glutamates may contribute to fibromyalgia symptoms for many

  [ 82 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 9, 2012


Article:
The effect of dietary glutamate on fibromyalgia and irritable bowel symptoms
- Source: Clinical and Experimental Rheumatology, Jul 4, 2012

By KF Holton, et al.

[Note: glutamic acid (glutamate) is “the chief excitatory neurotransmitter in the human brain” and aspartate can excite neurons in place of glutamate. Many neurodegenerative & cognitive problems are believed to involve the 'excitotoxin’ activity of glutamate/aspartate. Cells can synthesize one from the other, but these chemicals are both also common in foods. For example wheat gluten is 43% glutamate, milk protein 23%, gelatin 12%; MSG is glutamate and Aspartame is aspartate.]

Abstract:
Objectives: To examine the effects of a challenge with monosodium glutamate (MSG) as compared to placebo on the symptoms of fibromyalgia (FM), in participants who initially experienced >30% remission of symptoms on an excitotoxin elimination diet.

Methods: Fifty-seven FM patients who also had irritable bowel syndrome (IBS) were placed on a 4-week diet that excluded dietary additive excitotoxins including MSG and aspartame. Thirty-seven people completed the diet and 84% of those reported that >30% of their symptoms resolved, thus making them eligible to proceed to challenges.

Subjects who improved on the diet were then randomized to a 2-week double-blind placebo-controlled crossover challenge with MSG or placebo for 3 consecutive days each week. The primary outcome measure was total symptom score. Secondary outcome measures included visual analogue pain scales (VAS for FM and IBS), an IBS Quality of Life Questionnaire (IBS QOL) and the Fibromyalgia Impact Questionnaire-Revised (FIQR).

Repeated measures ANOVA was used to analyze crossover challenge results.

Results: The MSG challenge, as compared to placebo, resulted in:

• A significant return of symptoms (total symptom score, p<0.02);

• A worsening of fibromyalgia severity as determined by the FIQR (p<0.03);

• Decreased quality of life in regards to IBS symptoms (IBS QOL, p<0.05);

• And a non-significant trend toward worsening FM pain based on visual analogue scale (VAS, p<0.07).

Conclusions: These findings suggest that dietary glutamate may be contributing to FM symptoms in some patients. Future research on the role of dietary excitotoxins in FM is warranted.

Source: Clinical and Experimental Rheumatology, Jul 4, 2012. PMID:22766026, by Holton KF, Taren DL, Thomson CA, Bennett RM, Jones KD. Departments of Orthopedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA. [Email: holtonk@ohsu.edu]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health

Natural Remedies

Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
"It's Not Easy Being Green" - But It Is Healthy
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing