ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

List of diseases spread by deer tick grows, including malaria-like problems and potentially fatal en...

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients

Lyme disease confirmed in humans from southern states

Anticancer Properties Of Saffron

Teenager with stroke symptoms actually had Lyme disease

World Famous Joint Relief Formula Enhanced by Modern Science

The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from do...

Autistic and non-autistic brain differences isolated for first time

In a warmer world, ticks that spread disease are arriving earlier, expanding their ranges

Mayo Clinic Study of Thousands of Brains Reveals Tau as Driver of Alzheimer’s Disease

 
Print Page
Email Article

Combo of drugs affecting pain different ways helped central sensitization

  [ 9 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 7, 2012


Article:
Duloxetine and Pregabalin for Pain Management in Multiple Rheumatic Diseases Associated with Fibromyalgia
– Source: Pain Practice, Nov 5, 2012 By Chiara Angeletti, MD, et al.

[Note: Duloxetine (Cymbalta) is a serotonin and norepinephrine reuptake inhibitor ('new generation' antidepressant). Pregabalin (Lyrica) is an anticonvulsant. Both are drugs that may be prescribed for fibromyalgia symptoms in the US. Their modes of action are not entirely understood but generally it is thought that duloxetine works on the nerve pathway that inhibits pain, and pregabalin acts on the parts of the nerve that conduct pain signals.]

Abstract: The fibromyalgia syndrome (FMS) is characterized by chronic and widespread musculoskeletal pain and soreness accompanied by sleep disorders, chronic fatigue and affective disorders. FMS is often associated with other forms of immuno-rheumatic diseases.

Although FMS pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by "central sensitization," which is common to many other painful conditions.

The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new-generation antidepressants, when FMS complicates a rare pathology called Cogan's syndrome [rheumatic disease involving eye and ear inflammation].

The association of two drugs might noticeably affect the molecular mechanisms of difficult pain, thus solving painful conditions of multifactorial origin.

Source: Pain Practice (Publication of the World Institute of Pain), Nov 5, 2012. PMID:23126475. Angeletti C, Guetti C, Piroli A, Angeletti PM, Paladini A, Ciccozzi A, Marinangeli F, Varrassi G. Anesthesiology and Pain Medicine, Department of Health Sciences, University of L'Aquila, Italy. [Email: chiara.angeletti@gmail.com]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing