ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

New Option For Chronic Fatigue Syndrome

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

Stop Bacteria With Nature's Antibiotics

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

New Test Shows Promise in Identifying New Drugs to Treat Lyme Disease

Coenzyme Q10 Helps Veterans Battle Gulf War Illness Symptoms

Strengthen Cell Function with Energy-Boosting Niagen

Vitamin D deficiency increases poor brain function after cardiac arrest by sevenfold

Dietary Flavanols Reverse Age-Related Memory Decline

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

 
Print Page
Email Article

The Effects of Influenza Vaccination on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis - Source: International Journal of Clinical Medicine, Nov 2012

  [ 40 votes ]   [ Discuss This Article ]
By EW Benu, SM Marshall-Gradisnik, et al. • www.ProHealth.com • November 23, 2012


[Note: to view the full text PDF of this article, click here. The findings of this small trial suggest that flu shots may provide immunity, but the tradeoff is that later they may create dysfunctional, potentially toxic immune reactions not seen in controls.]

Immune dysfunction is a hallmark of Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME). The purpose of this pilot study was to identify the effects of influenza vaccination on immune function in patients with CFS/ME.

We included 7 patients meeting the Centre for Disease Control and Prevention criteria (CDC 1994) for ME/CFS and 8 control subjects. Bloods were collected from all participants prior to vaccination with Influvac, a trivalent inactivated influenza vaccine (TIV), 14 and 28 days following vaccination. The immune parameters examined include Natural Killer (NK) phenotypes, NK cytotoxic activity, FOXP3 and Th1/Th2/Th17 related cytokines. Flow cytometric protocols were employed.

• There was no significant difference in NK phenotypes and Tregs numbers between CFS/ME patients and healthy controls.

• However, NK activity was significantly decreased at baseline and at 28 days while at 14 days it was significantly increased in the CFS/ME patients compared to the healthy controls.

• Th1 pro-inflammatory cytokines were much more increased in the CFS/ME patients at 28 days compared to the non-fatigued controls.

• Only one Th2 cytokine, IL-4, was increased in the CFS/ME participants. FOXP3 expressing Tregs were significantly increased only at day 28 post vaccination in the CFS/ME patients compared to the healthy controls.

• Self-rated well being was lower for patients at day 28 while at baseline and day 14 no differences were observed.

In this pilot study immunization with influenza vaccine is accompanied by a degree of immune dysregulation in CFS/ME patients compared with controls.

While vaccination may protect CFS/ME patients against influenza, it has the ability to increase cytotoxic activity and pro-inflammatory reactions post vaccination.

The role of Tregs [regulatory T cells] in promoting a toxic effect at 28 days post-vaccination in our patient group cannot be ruled out. The benefits of influenza vaccine still likely outweigh the risks CFS/ME patients experience following vaccination.

Source: International Journal of Clinical Medicine, Nov 2012 by Brenu EW, van Driel M, Staines DR, Kreijkamp-Kasper S, Hardcastle SL, Marshall-Gradisnik SM. Faculty of Health Science and Medicine, Population Health and Neuroimmunology Unit, Bond University, Robina, QLD, Australia; School of Medical Science, Griffith Health Institute, Griffith University, Gold Coast Campus, Gold Coast; Discipline of General Practice, School of Medicine, University of Queensland, Brisbane, Australia; Queensland Health, Gold Coast Public Health Unit, Robina, Gold Coast, QLD, Australia. [Email: e.brenu@griffith.edu.au]
 




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Immune Support Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
How I Found My Long-Lost Energy How I Found My Long-Lost Energy

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing