ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

New Science Destroys the Saturated Fat Myth

Diet Affects Men’s and Women’s Gut Microbes Differently

New Lyme guidelines promote options and informed choice

Phases of clinical depression could affect treatment

“Worm pill” could ease autoimmune disease symptoms

Eating Baked or Broiled Fish Weekly Boosts Brain Health, Pitt Study Says

Scientists Look for Biomarkers to Improve Treatment of Painful Bladder Condition

New culprit identified in metabolic syndrome

Low vitamin D levels linked to increased risks after noncardiac surgery

Preserving Cognitive Function with Aging

 
Print Page
Email Article

CFS Patients with POTS: Clinically Distinct Subgroup

  [ 448 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 6, 2012


Article:
Clinical characteristics of a novel subgroup of chronic fatigue syndrome patients with postural orthostatic tachycardia syndrome
– Source: Journal of Internal Medicine, Dec 4, 2012

By I Lewis, J Newton, et al.

[Note: POTS is one of five types of orthostatic intolerance that collectively affect nearly all chronic fatigue syndrome (ME/CFS) patients, according to Dr. David Bell - see “Orthostatic Intolerance and Chronic Fatigue Syndrome.”]

Abstract:
Objectives: A significant proportion of patients with chronic fatigue syndrome (CFS) also have postural orthostatic tachycardia syndrome (POTS). We aimed to characterize these patients and differentiate them from CFS patients without POTS in terms of clinical and autonomic features.

Methods: A total of 179 patients with CFS (1994 Centers for Disease Control and Prevention criteria) attending one of the largest Department of Health-funded CFS clinical services were included in the study.

Outcome measures were:

1. Symptom assessment tools including the fatigue impact scale, Chalder fatigue scale, Epworth sleepiness scale (ESS), orthostatic grading scale (OGS) and hospital anxiety and depression scale (HADS-A and -D, respectively),

2. Autonomic function analysis including heart rate variability and

3. Hemodynamic responses including left ventricular ejection time and systolic blood pressure drop upon standing.

Results:

CFS patients with POTS (13%, n=24) were:

• Younger (29 +/- 12 vs. 42 +/- 13 years, P<0.0001) [probability the difference resulted by chance less than 1 in 10,000],

• Less fatigued (Chalder fatigue scale, 8 +/- 4 vs. 10 +/- 2, P=0.002),

• Less depressed (HADS-D, 6 +/- 4 vs. 9 +/- 4, P=0.01),

• And had reduced daytime hypersomnolence [hypersomnolence is excessive sleeping/sleepiness] (ESS, 7 +/- 6 vs. 10 +/- 5, P=0.02)…

…Compared with patients without POTS.

In addition, they exhibited greater orthostatic intolerance (OGS, 11 +/- 5; P<0.0001) and autonomic dysfunction.

A combined clinical assessment tool of Epworth sleepiness scale 9 or less and orthostatic grading scale 9 or more identifies accurately CFS patients with POTS with 100% positive and negative predictive values.

Conclusions:

The presence of POTS marks a distinct clinical group of CFS patents, with phenotypic features differentiating them from those without POTS.

A combination of validated clinical assessment tools can determine which CFS patients have POTS with a high degree of accuracy, and thus potentially identify those who require further investigation and consideration for therapy to control heart rate.

Source: Journal of Internal Medicine, Dec 4, 2012. PMID:23206180, by Lewis I, Pairman J, Spickett G, Newton JL. Institute for Ageing & Health, Newcastle University, Newcastle, UK. [Email: julia.newton@ncl.ac.uk]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
How I Found My Long-Lost Energy How I Found My Long-Lost Energy

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing