ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Cassia Bark Oil: Why It's Valuable in Traditional Chinese Medicine

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Magnesium Protects Against Stroke, Heart Disease and Diabetes

 
Print Page
Email Article

Regulating Leptin Hormone may Help Fight Autoimmune Disease

  [ 46 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 20, 2003


The hormone leptin, primarily produced in fat cells, helps regulate food intake, metabolism and reproduction. It has also been shown to promote and sustain the body’s immune response by binding to T lymphocytes - the frontline cells that protect against infection.

The disease experimental autoimmune encephalomyelitis (EAE) in mice is currently used by researchers as a model of human multiple sclerosis (MS). The disease is characterized by the production of autoreactive T lymphocytes that turn against the body and attack cells within the brain and spinal cord, first inducing weight loss and ultimately resulting in paralysis.

In the January 15 issue of the Journal of Clinical Investigation, Giuseppe Matarese and colleagues at Università di Napoli "Federico II", Napoli, Italy report that just prior to developing the clinical symptoms of EAE, mice experience a significant burst of leptin which correlates with a reduction in food intake and weight loss. Furthermore, subjecting mice to acute starvation, which prevents the production of leptin, was found to delay the onset and reduce the severity of disease. In addition, leptin secretion from T lymphocytes was found to further contribute to overall leptin production during EAE.

"Once again we witness the remarkable choreography of molecules related to body weight and energy metabolism and the parallel roles of these same molecules in the finely tuned immune response" stated Dr. Lawrence Steinman and colleagues at Stanford University, California in their accompanying commentary. They go on to say that "these results imply that in autoimmunity, stress may be beneficial, and that short-term starvation may help reverse disease." Stress is detrimental and eating is recommended when fighting bacterial infections, however it appears that in the case of autoimmunity, the opposite holds true - stress and fasting is helpful.

These results suggest that leptin actively contributes to the pathogenesis of EAE, influencing both its onset and clinical severity. Interestingly, leptin is produced at much higher levels in females than males, which may account for the higher susceptibility of females to autoimmune diseases, a fact that has long puzzled scientists. The authors suggest that modulating leptin concentration through dietary approaches, and/or the administration of drugs that interfere with the body’s own production of leptin, may have potential utility in the treatment of MS and other autoimmune diseases.



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map