Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

For veterans with Gulf War Illness, an explanation for the unexplainable symptoms

Acupuncture reduces hot flashes in breast cancer survivors

SURVEY: Has Your Illness Affected What You Eat?

DePaul Study Recruiting Participants

Recent Research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effe...

Cocoa flavanols lower blood pressure and increase blood vessel function in healthy people

Mediterranean Diet Plus Olive Oil Associated with Reduced Breast Cancer Risk

Chemical exposure linked to rising diabetes, obesity risk

Researchers find 'dormant' parasite cysts are actually quite active

Resveratrol impacts Alzheimer's disease biomarker

Print Page
Email Article

Alpha-1 antitrypsin and chronic fatigue syndrome: a case study from pathophysiology to clinical practice

  [ 5 votes ]   [ 1 Comment ]
By J. Alegre et al. • • April 8, 2014

Editor’s Comment: Alpha -1 Antitrypsin protects tissues from enzymes of inflammatory cells. The FDA has approved the use of three alpha 1-antitrypsin products derived from human plasma: Prolastin, Zemaira, and Aralast. Alpha -1 Antitrypsin treatment is extremely expensive.

By J. Alegre et al.


Background: Several lines of evidence support the involvement of inflammatory and immunologic abnormalities in chronic fatigue syndrome (CFS). Since recent studies have shown that alpha-1 antitrypsin (AAT) possesses anti-inflammatory properties, the potential therapeutic effect of AAT treatment on CFS has been investigated.

Case presentation: A 49-year-old woman diagnosed with CFS was treated with intravenous infusions of a human plasma-derived AAT concentrate (60 mg/kg body weight weekly for 8 consecutive weeks). The patient's monocyte elastase, a regulator of inflammatory processes, was 1170 U/mg.

At completion of treatment, improvement in maximal workload was observed (54.0-71.7% of predicted). Additionally, amelioration in working memory (scores: 83-94) and perceptual organization (scores: 75-83) were detected on the Wechsler Adult Intelligence Scale-III test. Monocyte elastase decreased to a normal range (<150 U/mg).

Improvement in functional capacity allowed the patient to work in part-time employment.

Conclusion: These findings suggest a possible role for AAT in the treatment of CFS.

Source: Alegre J, Camprubí S, García-Quintana A. Pain Manag. 2013 Mar;3(2):119-22. doi: 10.2217/pmt.12.84.

Please Discuss This Article:   Post a Comment 

A1AT study
Posted by: ashley96
Apr 24, 2014
A very interesting case report. Sadly this is a very expensive drug although a company in Italy were
apparently looking at a way of delivering the same via a nose spray a few years ago for A1At deficiency. They were bought up and nothing heard of it since. A few other studies are looking at
the wider impact of A1AT in other inflammatory disorders, as well as diabetes.Like everything else
cost will inevitably put a break on this promising area of research. Just a note, but it doesn't say if the patient had A1AT deficiency or not.
Reply Reply
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Magnesium: An Essential Supplement for ME/CFS Magnesium: An Essential Supplement for ME/CFS
Safely Burn Away Body Fat Safely Burn Away Body Fat

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing