Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Chocolate's Potential Health Benefits – and its Effect on Chronic Fatigue Syndrome Patients

High dose vitamin D3 supplementation lowers inflammatory T cells in multiple sclerosis patients

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Essential Oils - How and Where to Use Them

The Link Between Vitamin C And Optimal Immunity

SURVEY: What Is Your Diagnosis?

Liposomes Deliver Optimal Nutrient Absorption

Why Does Your Nose Run When It's Cold Outside?

What's So Great About Grape Seed?

How Your Mitochondria Influence Your Health

 
Print Page
Email Article

Iron deficiency predicts outcome in acute heart failure

  [ 2 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 4, 2014


Press Release: European Society of Cardiology, May 17, 2014

Iron deficiency (ID), defined as a combination of depleted body iron stores and unmet cellular iron requirements, identified acute heart failure (AHF) patients with the worst outcomes, reported a Polish observational study in yesterday’s Late Breaking Trial session.

Iron is an essential micronutrient involved in cellular energy and metabolism. “In previous studies iron deficiency has been shown to be common in patients with chronic HF and to aggravate symptoms and worsen clinical outcomes,” explained study presenter Ewa Jankowska. The current study, she added, is the first to look at iron status in AHF.

Two major pools of iron are known to exist in the body: stored iron (hepatocytes, reticuloendothelial cells, and syderoblasts) and utilized iron (circulating iron and intracellular iron in virtually all cells). “Diagnosis of ID needs to take both these pools into consideration since they closely interact with each other and iron can be physiologically transferred between these departments,” explained Jankowska, from Wroclaw Medical University, Poland.

In the prospective study, 165 patients with a diagnosis of AHF as the primary cause of hospitalization had their serum hepcidin measured on admission as a marker for depleted iron stores, and serum soluble transferring receptor (sTfR) as a marker of unmet cellular iron requirements. The primary end-point was all-cause death, with 33 deaths occurring by 12 months follow-up.

Depleted body iron stores were diagnosed when serum hepcidin was <14.5 ng/ mL (the 5th percentile among healthy controls); while depleted utilized iron stores were diagnosed when serum sTfR was>1.59 mg/L (the 95th percentile among healthy controls). Four different groups of patients were defined: those with the most severe ID (low hepcidin and high sTfR); isolated low hepcidin; isolated high sTfR; and preserved iron status (neither low hepcidin nor high sTfR).

Results show iron deficiency (defined as low hepcidin and high sTfR) was demonstrated in 37% of patients (61), whereas isolated high sTfR was found in 29% (48) and isolated low hepcidin in 9 % (15). Mortality at 12 months was 41 % [95% CI 29-53%] for patients with low hepcidin and high sTfR compared to 15% [95%CI 5-25%] for patients with isolated low hepcidin levels and 0% for patients with preserved iron status (p<0.001).

“Indices of iron status were only weakly, if at all, associated with haemoglobin. Profound ID (low hepcidin and high sTfR) was seen in both anaemics and non-anaemics,” said Jankowska, adding that iron status appeared to be severely deranged as serum hepcidin levels were extremely low and serum sTfR high.

“Profound ID confirmed as depleted iron stores and iron avidity allows for the identification of AHF patients with particularly poor outcomes. This holds equally for both anaemic and non anaemic patients. Correction with iron supplementation may offer an attractive therapeutic option targeting abnormal metabolism in patients with AHF who still have unacceptably high mortality. We hope to initiate such a trial soon” said Jankowska.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

How Glutathione Can Save Your Life

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood

FIBROMYALGIA
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
LYME DISEASE
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
FORUMS
Fibromyalgia
M.E. & CFS
Lyme Disease
General Health
WHOLESALE
AFFILIATES GUARANTEE
PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing