ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial

Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia bu...

New Envita Study Shows Chronic Lyme Disease "Fools" Immune System, Resistant to Antibiotics

Safely Burn Away Body Fat

Omega-3 fatty acids boost B vitamin brain benefit

Substantial health threat: Never-before-seen tick-borne disease

Trigger identified that likely unleashes autoimmune disease

Lyme Advocates Call on IDSA to Focus on Patient Care Instead of Attacking Those in Distress

Zinc deficiency linked to chronic inflammation

New records of the Lyme disease bacterium in ticks collected from songbirds in central and eastern C...

 
Print Page
Email Article

Investigation of humoral immune response towards persisting Epstein-Barr virus infections in multiple sclerosis and chronic fatigue syndrome using peptide microarrays

  [ 3 votes ]   [ Discuss This Article ]
By Aaron Castro et al. • www.ProHealth.com • June 12, 2014


By Aaron Castro et al.

Abstract

Most humans carry a considerable number of persisting viral infections, frequently in a latent state. Chronic infections may intermittently reactivate especially under immune suppression and play an important role as trigger or cofactor for autoimmune diseases and cancer.

Correlation of such infections with diseases is difficult. An analysis of antibody repertoire in chronic infection may provide information about patterns of virus reactivation. Following primary infection the herpes virus 4 (EBV) results in persistent mostly asymptomatic latent infection.

About 95% of the adult population are EBV seropositive. EBV infections are known as cofactors for various diseases such as lymphomas, multiple sclerosis and chronic fatigue syndrome. The detailed mapping of humoral immune response in human serum samples allows a high resolution analysis of the antibody repertoire against EBV antigens.

We developed a peptide microarray platform with peptide libraries of up to 6900 members. Here we present data using a library of peptide scans through major EBV antigens from incubations with serum samples of healthy human donors, patients diagnosed with chronic fatigue syndrome or multiple sclerosis.

Even though there are shared epitopes between the specimens and cohorts, different epitope patterns are observed for a number of antigens and antigen areas. The patterns of antibody responses could be of diagnostic value for multiple sclerosis and chronic fatigue syndrome.

Source: Aaron Castro, Nikolaus Pawlowski, Ulf Reimer, Janina Jansong, Madlen Löbel, Klemens Ruprecht, and Carmen Scheibenbogen. Investigation of humoral immune response towards persisting Epstein-Barr virus infections in multiple sclerosis and chronic fatigue syndrome using peptide microarrays. The Journal of Immunology, May 1, 2014, vol. 192 no. 1 Supplement 69.36.



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood
Coping When Colds or Flu Catch Up with You

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing