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Considerations in establishing a post-mortem brain and tissue bank for the study of myalgic encephalomyelitis/chronic fatigue syndrome: a proposed protocol

  [ 5 votes ]   [ 1 Comment ]
By Luis Nacul et al. • www.ProHealth.com • July 1, 2014


Note: You can read the full article here.

By Luis Nacul et al.

Abstract (provisional)

Background: Our aim, having previously investigated through a qualitative study involving extensive discussions with experts and patients the issues involved in establishing and maintaining a disease specific brain and tissue bank for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), was to develop a protocol for a UK ME/CFS repository of high quality human tissue from well characterised subjects with ME/CFS and controls suitable for a broad range of research applications. This would involve a specific donor program coupled with rapid tissue collection and processing, supplemented by comprehensive prospectively collected clinical, laboratory and self-assessment data from cases and controls.

Findings: We reviewed the operations of existing tissue banks from published literature and from their internal protocols and standard operating procedures (SOPs). On this basis, we developed the protocol presented here, which was designed to meet high technical and ethical standards and legal requirements and was based on recommendations of the MRC UK Brain Banks Network and the Brain Net Europe II network.

The facility would be most efficient and cost-effective if incorporated into an existing tissue bank. Tissue collection would be rapid and follow robust protocols to ensure preservation sufficient for a wide range of research uses. A central tissue bank would have resources both for wide-scale donor recruitment and rapid response to donor death for prompt harvesting and processing of tissue.

Conclusion: An ME/CFS brain and tissue bank could be established using this protocol. Success would depend on careful consideration of logistic, technical, legal and ethical issues, continuous consultation with patients and the donor population, and a sustainable model of funding ideally involving research councils, health services, and patient charities. This initiative could revolutionise the understanding of this still poorly-understood disease and enhance development of diagnostic biomarkers and treatments.

Source: Luis Nacul, Dominic G O'Donovan, Eliana M Lacerda, Djordje Gveric, Kirstin Goldring, Alison Hall, Erinna Bowman and Derek Pheby. BMC Research Notes 2014, 7:370 doi:10.1186/1756-0500-7-370




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Article Comments Post a Comment

Post-mortem brain and tissue bank
Posted by: many turtles
Jul 24, 2014
I am a registered organ donor and have given serious consideration regarding donating my brain/tissues to the ME/CFIDS physicians. This is something that may make a tremendous impact on the why and how of these diseases. After over 16 years of dealing with the above I have prayed for a definitive marker AND a CURE. If it is possible to establish a post-mortem brain and tissue bank, specifically for these diseases, perhaps CFIDS/ME can be eliminated. As for the issues of obtaining such, coordination with several other medical based programs, could assist with the harvesting and recovery for medical exploration.

Please consider this as one of the options for total organ donor requests.

Sincerely,
P.R.
CA, USA
Reply Reply
 
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