ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Vitamin E intake critical during 'the first 1,000 days'

Turmeric compound boosts regeneration of brain stem cells

Lower risk of mortality over thirteen year period in association with higher levels of vitamin D

Reverse Mitochondrial Damage

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

VIDEO: Beautiful Clouds - Relaxation and Meditation

CoQ10: The Longevity Factor

Elevated plasma biomarkers of chronic inflammation in Gulf War illness

 
Print Page
Email Article

Unsuspected aspect of immune regulation revealed: Role of B cells

  [ 6 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 6, 2014


Unsuspected aspect of immune regulation revealed: Role of B cells
Press Release: Garvan Institute, July 2, 2014. A discovery by Australian immunologists, uncovering an additional role for antibody-making ‘B cells’, is considered important enough by the American Association of Immunologists to rank it among the top 10% of articles in the latest issue of The Journal of Immunology, off the press today.

The finding by Senior Research Assistant Stacey Walters and Associate Professor Shane Grey, from Sydney’s Garvan Institute of Medical Research, shows that B cells also participate in the development of ‘regulatory T cells’.

T cells develop in the thymus gland, a soft triangular organ in the chest cavity. From a ‘naïve’, or undifferentiated, state they are gradually ‘educated’ to become helpers, or warriors, or regulators.

Until now, the only non-thymic cells known to educate the regulators were dendritic cells, which travel to the thymus to deliver ‘antigen’, samples of substances toxic to the body. We now know that B cells can do the same thing.

B cells have been thought to specialise only in the production of antibodies. As newfound educators of T cells as well, B cells become much more interesting and complex characters, potentially useful in helping to prevent organ rejection, or control inflammatory bowel disease, or quell autoimmune conditions.

That is because regulatory T cells control how killer T cells behave – and can effectively prevent the warriors from attacking ‘self’ tissue, or tissue perceived as foreign. In the case of organ transplantation, several studies have shown that high levels of regulatory T cells can prevent organ rejection.

“Regulatory T cells are critical in the outcome of an immune response – so anything that in turn regulates them becomes very interesting to immunologists,” said Associate Professor Grey.

“Right now there are clinical trials around the world looking to expand populations of these cells in patients. Researchers are also working on ways to grow regulatory cells in the laboratory – to infuse into patients as therapy.”

“Everyone is interested in finding ways to treat autoimmunity and prevent transplant rejection. Expansion of regulatory T cells should help in both cases.”

“Our finding suggests it should be possible to set up systems that harness B cells to expand regulatory cells.”

The Garvan lab members worked with mice genetically modified to express high levels of ‘BAFF’, a substance that increases survival of B cells. The higher number of B cells overall allowed researchers to track the activity of B cells in the thymus.

“It has been known for years that some B cells travel to the thymus, but no-one has understood why,” said Stacey Walters.

“Our experiments showed clearly that B cells participated in the creation of regulatory T cells – the more B cells that were in the thymus, the higher the number of regulatory cells generated. That direct correlation raises interesting possibilities.”

“One possibility is using BAFF, a non-toxic substance, to ramp up the B cell count of patients before transplant procedures. It will be very interesting to test whether or not that would prevent rejection.”

Journal Reference: S. N. Walters, K. E. Webster, S. Daley, S. T. Grey. A Role for Intrathymic B Cells in the Generation of Natural Regulatory T Cells. The Journal of Immunology, 2014; 193 (1): 170 DOI: 10.4049/%u200Bjimmunol.1302519


Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing