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CoQ10 supplementation reduces statin-related muscle pain in randomized trial

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By Life Extension • • November 26, 2014

CoQ10 supplementation reduces statin-related muscle pain in randomized trial
Reprinted with the kind permission of Life Extension.

November 12 2014. A double-blinded trial reported in the most recent issue of Medical Science Monitor found a reduction in mild to moderate statin drug-induced muscle symptoms in men and women who supplemented with coenzyme Q10 (CoQ10). Myalgia is the most common adverse effect associated with the use of statins, which renders those who are intolerant of the symptoms unable to avail themselves of the drugs' potential benefits.
Researchers at the university of Ljubljana Medical Center in Slovenia randomized 50 middle-aged statin users who reported mild to moderate muscle pain for at least six months to receive 50 milligrams CoQ10 or a placebo twice per day for 30 days. Questionaires concerning pain severity and intereference with daily activities were administered before and after treatment, and blood samples were analyzed for lipid, liver enzyme and muscle enzyme levels.
By the end of the study, muscle pain intensity was decreased by 33% and pain interference was reduced by 40% among those who received CoQ10 while remaining unchanged in the placebo group. Seventy-five percent of the CoQ10 group were found to have experienced a decrease in statin-related muscle symptoms, with no change in lipids, liver enzymes or muscle enzymes.
"The present study revealed that by simple coenzyme Q10 supplementation of the regular statin treatment, associated muscle pain in the mild-to-moderate symptoms group could be significantly reduced," Ajda Skarlovnik and colleagues conclude. "Consequently, it may lead to lower interference with daily activities and higher compliance with statin treatment. These observations mean a better quality of life, besides adequate cardiovascular protection, which is the primary goal of statin therapy. The results of the present study are very promising, but require further testing in larger clinical trials, mainly to allow them to be generalized."

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