ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Give Your Health a Much-Needed Boost With Geranium

The Role of Resveratrol in Achieving Optimal Health

 
Print Page
Email Article

Green tea extract may have neuroprotective effects in Parkinson's disease

  [ 29 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 2, 2002


Source: The Lancet, Volume 358, Number 9279, 04 August 2001

Researchers from Israel have found that a phenolic compound in green tea is a strong neuroprotectant in two different models of Parkinson's disease. The results were presented at the 14th International Congress on Parkinson's Disease in Helsinki, Finland, on July 27, 2001.

The investigators, led by Moussa Youdim (Technion-Faculty of Medicine, Haifa, Israel), used microarrays, or "gene chips", to study the effects of epigallocatechin-3-gallate (EGCG), which comprises about a third of the polyphenol content of green tea extracts. They found that treating rodents with MPTP or 6-hydroxydopamine, the two classic inducers of experimental parkinsonism, causes a suite of 51 genes to change their expression levels, in some cases increasing by 1000% or more. These include genes for NFB, and proinflammatory cytokines, such as interleukin 1ß. However, if the rodents receive oral EGCG for 2 days before treatment, these changes in gene expression are suppressed, and the rodents are protected from the harmful effects of each toxin.

EGCG is a powerful iron chelator, which may partly explain its neuroprotective effects: iron accumulation has been implicated in a range of neurodegenerative diseases (see Lancet 2001; 358: 302), and iron accumulates in neurons in the substantia nigra of patients with Parkinson's disease.

To test the applicability of EGCG in Parkinson's disease, Youdim is currently using microarrays to see whether human brain with Parkinson's disease also shares these genetic changes. However, Youdim cautions that a long line of putative neuroprotectants have been tried, and failed, in human beings (although he is optimistic enough to have applied for a patent on EGCG). But he also notes: "Cell death is not just one process; it's a domino effect involving many pathways. I don't believe we can protect neurons with one single drug; we'll need a cocktail of agents to interrupt these different pathways."

By Richard Robinson



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map