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A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients with Lyme Disease

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By J. T. Crowley et al. • www.ProHealth.com • June 18, 2015


By J. T. Crowley et al.
 
Abstract
 
To discover novel autoantigens associated with Lyme arthritis (LA), we identified T cell epitopes presented in vivo by HLA-DR molecules in patients' inflamed synovial tissue or joint fluid and tested each epitope for autoreactivity.
 
Using this approach, we identified the highly expressed human protein, apolipoprotein B-100 (apoB-100), as a target of T and B cell responses in a subgroup of LA patients. Additionally, the joint fluid of these patients had markedly elevated levels of apoB-100 protein, which may contribute to its autoantigenicity.
 
In patients with antibiotic-refractory LA, the magnitude of apoB-100 antibody responses correlated with increased numbers of plasma cells in synovial tissue, greater numbers and activation of endothelial cells, and more synovial fibroblast proliferation.
 
Thus, a subset of LA patients have high levels of apoB-100 in their joints and autoreactive T and B cell responses to the protein, which likely contributes to pathogenic autoimmunity in patients with antibiotic-refractory LA.
 
Source: Crowley JT, Drouin EE, Pianta A, Strle K, Wang Q, Costello CE, Steere AC. A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients with Lyme Disease. Journal of Infectious Diseases, online first, 2015 May 26.




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