ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Hop Oil: A Safe Sleep Aide

Lutein — An Important Nutrient for Eye and Brain Health

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

 
Print Page
Email Article

Arthritis Drug Suppresses Cancer Development by Stopping Action of Key Protein

  [ 58 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 7, 2003


Researchers at The University of Texas M. D. Anderson Cancer Center have, for the first time, identified the molecular pathway by which a commonly prescribed arthritis medication inhibits the growth of cancer.

Before this study, scientists had linked use of celecoxib capsules (commonly known as Celebrex) to prevention of cancer, but the way in which the medication acted in cancer cells was unknown.

Now, investigators have found that celecoxib capsules stop a key transcription factor known as Sp1 from turning on multiple genes in cancer cells known to be associated with cancer growth. One of those genes triggers production of vascular endothelial growth factor (VEGF), the predominant angiogenic factor that leads blood vessels to grow to feed tumors.

The findings were published in the Proceedings for the 2003 Annual Meeting of the American Association for Cancer Research.

"Our results provide a novel molecular mechanism for the antitumor activity of celecoxib," says Keping Xie, M.D., Ph.D., assistant professor in the department of gastrointestinal medical oncology.

Xie adds that although the study was conducted in models of pancreatic cancer, the results likely describe how celecoxib interferes with development of a number of common cancers that all involve the Sp1/VEGF pathway.

"Pancreatic cancer overexpresses Sp1, which then drives VEGF overexpression," says Xie. "This same molecular activity is also found in colon, prostate, gastric and breast cancer."

Now that the mechanism by which celecoxib inhibits cancer growth is known, it may be possible to tailor the drug to be even more powerful, Xie says. Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) known as a cox-2 inhibitor, and this new study demonstrates that cox-2 inhibits VEGF through the Sp1 transcription factor.

The researchers used both pancreatic cell cultures and an animal model of the disease to draw their conclusions. They treated pancreatic cancer cells with celecoxib and found it suppressed VEGF at both the genetic level (messenger RNA) and at protein expression, in a dose-dependent manner _ increasing amounts of the drug produced increasing suppression. Laboratory tests then demonstrated that celecoxib treatment reduced the ability of Sp1 to promote genetic activity, and studies with a pancreatic cancer animal model showed the drug inhibited tumor growth and metastasis, which correlated with reduced VEGF expression.

"The antitumor activity was consistent with inhibition of angiogenesis as determined by evaluating tumor microvessel formation, which correlated with decreased Sp1 activity and VEGF expression," says Xie.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map