ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Cassia Bark Oil: Why It's Valuable in Traditional Chinese Medicine

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

 
Print Page
Email Article

Researchers Find Blacks Also Have Telltale Osteoarthritis Protein

  [ 144 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 18, 2003


By DAVID WILLIAMSON
UNC News Services

Medical scientists have known for the past decade that levels of an important protein known as COMP were higher in cartilage, ligaments, tendons and joint lubricating fluid of whites with osteoarthritis than in those without the painful, degenerative illness.

Now, researchers at the University of North Carolina at Chapel Hill have shown for the first time that the same thing is true in blacks. They also found average levels of the protein to be higher in blacks, -- both patients and others -- than in whites and higher among white men than among white women.

“These discoveries are likely to be important in the search for better ways to predict who is at strong risk of developing osteoarthritis, who had it already and whose illness is most likely to progress,” said Dr. Joanne M. Jordan, associate professor of medicine and orthopaedics at the UNC School of Medicine. “No one had ever studied African-Americans in this way before.”

Just knowing how much of the protein, which is considered an emerging “biomarker” of the illness, is naturally present in the different races and sexes could become a major tool for determining when the illness occurs and when it advances, said Jordan, also adjunct professor of epidemiology at the UNC School of Public Health. “We must take these differences into account. An African-American person, for example, could be falsely considered at high risk because of elevated COMP when in fact COMP levels are just higher in blacks normally.”

A report on the new findings appears in the March issue of the medical journal, Arthritis & Rheumatism. More than 750 men and women of both races participated in the study, which involved measuring COMP levels in volunteers with no X-ray evidence of osteoarthritis. Some of the differences recorded may stem from differences in joint size and total body cartilage content.

The National Institute of Arthritis, Musculoskeletal and Skin Diseases and several pharmaceutical companies have begun a public-private consortium, called the Osteoarthritis Initiative, to find biomarkers of osteoarthritis that could help evaluate osteoarthritis progression, Jordan said.

“Currently, to be able to market an osteoarthritis drug that actually modifies the disease and not just treats symptoms, it takes a clinical trial of at least two to three years,” she said. “Because we do not have any good way to measure progression of osteoarthritis, the goal of the Osteoarthritis Initiative is to identify biomarkers that could shorten this time by giving us better indicators of progression.”

COMP, short for cartilage oligometic matrix protein, a glycoprotein compound that includes carbohydrates, promises to be a strong indicator, the physician said.

Jordan leads the Centers for Disease Control and Prevention and National Institutes of Health-funded Johnston County Osteoarthritis Project. That unique research involves more than 3,000 volunteers and is the largest study ever done of arthritis in both black and white rural communities.

Earlier work she and colleagues did showed, among other things, that significantly more people may have legs of slightly unequal length than doctors previously believed. They also discovered that COMP increases markedly in the blood of people with hip or knee osteoarthritis even before X-rays reveal joint damage.

“The best things people can do to minimize knee and hip osteoarthritis are to avoid activities that put heavy physical demands on joints and especially to lose any excess weight,” she said. “Also, evidence suggests it’s important to keep thigh and other leg muscles strong through non-stressful exercise.”

They further found that COMP levels correspond closely with pain that patients with undiagnosed osteoarthritis report to doctors. People with five or more years of hip or knee pain, for example, showed about 33 percent more of the protein in their blood than people reporting no pain, Jordan said.

Osteoarthritis, the most common form of arthritis, afflicts almost a million North Carolinians and more than 21 million people nationally, including many adults over age 65, the physician said. Some estimates suggest that as many as 70 million Americans will suffer from some form of arthritis within the next 20 years as baby boomers age.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map