ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Blood Pressure Medications Not Equal, Researchers Say

  [ 22 votes ]   [ Discuss This Article ]
By Bruce M. Psaty, M.D., Ph.D.,Marco Pahor, M.D.,Michael H. Alderman, M.D. • • December 17, 2001

WINSTON-SALEM, N.C. - A blood pressure medicine's success at lowering pressure shouldn't be the only measure of its effectiveness, say researchers from Wake Forest University Baptist Medical Center and colleagues in an editorial in this week's Annals of Internal Medicine. "We all agree that high blood pressure should be lowered. New scientific evidence strongly suggests that it matters how we do it," said Curt Furberg, M.D., Ph.D., professor of public health sciences at Wake Forest.

"We tend to forget that drugs have multiple actions that may add to or subtract from the benefit of blood pressure lowering itself. Some drugs, for example, reduce the risks of heart attack and heart failure through other mechanisms. Therefore, which drug is used to control high blood pressure may be very important."

In their editorial, the authors argue that drugs that are equally effective at lowering pressure may vary widely in how well they prevent complications of high blood pressure - heart attacks, strokes and heart failure. They called for better ways of evaluating and testing hypertension drugs. "We point out that the intended use of hypertension drugs is to reduce the complications of high blood pressure, not just to lower pressure," said Furberg. "Adopting this view would require a change in the way these drugs are approved and promoted."

To prove their point that a drug's effectiveness shouldn't be measured by blood pressure-lowering alone, the authors gave examples of several recent studies.

· Part of the ALLHAT (Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack) study was stopped early when participants taking doxazosin (sold under the name Cardura®) had 25 percent more serious complications (heart failure and strokes) from hypertension than the group taking the much less expensive diuretic chlorthalidone. The participants in the Cardura group were twice as likely to develop or be hospitalized for heart failure.

· An analysis of four studies comparing blood pressure drugs found that ACE (angiotensin converting enzyme) inhibitors are more effective than other drugs in reducing the risk for heart attacks, but not stroke, in patients with diabetes.

· An analysis of nine studies comparing long-acting calcium channel blockers with other hypertension drugs found that the agents were equally effective at lowering pressure, but that calcium channel blockers were associated with 25 percent higher rates of heart attacks and heart failure.
"We've behaved as if blood pressure lowering drugs have only one effect," said Furberg. "These studies remind us that this is a simplistic view.

Prevention of cardiovascular complications is likely to be affected by the way in which blood pressure is lowered." The authors said new types of hypertension drugs should be compared head-to-head with the standard therapy, which is currently a low-dose diuretic. Rather than measuring how well the drugs lower pressure, the studies should compare their effectiveness at preventing heart attacks, strokes and congestive heart failure, the authors said.

"Treatment decisions should be based on the results from properly-designed research trials," said Furberg. "Relying on data about blood pressure-lowering alone may not be in the patients' best interest."

Co-authors were Bruce M. Psaty, M.D., Ph.D., from the University of Washington, Seattle; Marco Pahor, M.D., Wake Forest University Baptist Medical Center; and Michael H. Alderman, M.D., Albert Einstein College of Medicine, Bronx, N.Y.

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map