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Mitochondrial Myopathy in Follow-up of a Patient With Chronic Fatigue Syndrome

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By Fernando Galán et al. • www.ProHealth.com • October 4, 2015


Note: You can read the full article HERE.

By Fernando Galán et al.

Abstract

Introduction. Symptoms of mitochondrial diseases and chronic fatigue syndrome (CFS) frequently overlap and can easily be mistaken.

Methods. We report the case of a patient diagnosed with CFS and during follow-up was finally diagnosed with mitochondrial myopathy by histochemical study of muscle biopsy, spectrophotometric analysis of the complexes of the mitochondrial respiratory chain, and genetic studies.

Results. The results revealed 3% fiber-ragged blue and a severe deficiency of complexes I and IV and several mtDNA variants. Mother, sisters, and nephews showed similar symptoms, which strongly suggests a possible maternal inheritance. The patient and his family responded to treatment with high doses of riboflavin and thiamine with a remarkable and sustained fatigue and muscle symptoms improvement.

Conclusions. This case illustrates that initial symptoms of mitochondrial disease in adults can easily be mistaken with CFS, and in these patients a regular reassessment and monitoring of symptoms is recommended to reconfirm or change the diagnosis.

Source: Fernando Galán, Isabel de Lavera, David Cotán, José A. Sánchez-Alcázar. Mitochondrial Myopathy in Follow-up of a Patient With Chronic Fatigue Syndrome. Journal of Investigative Medicine High Impact Case Reports July-September 2015 vol. 3 no. 3 2324709615607908  




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