Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Meet the ProHealth Editors

Best Herbs to Help With Insomnia

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Acupressure reduced fatigue in breast cancer survivors

Don't Skimp on Your Skin — Try Rosehip Oil Now

 
Print Page
Email Article

Consortium to Detect Causes for Arthritis of the Spine

  [ 26 votes ]   [ Discuss This Article ]
By News release • www.ProHealth.com • April 8, 2000


The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has awarded $4.5 million to establish the North American Spondylitis Consortium (NASC) to search for genes that determine susceptibility to ankylosing spondylitis (AS), a rare but painful inflammatory disease of the spine, primarily affecting men. The gene HLA-B27 is known to be linked to AS; however, researchers believe that there are additional genes associated with its pathogenesis (the origin and course of a disease).

The consortium, made up of researchers with a background in clinical and genetic research in AS, hopes to learn more about genes that play a role in the disease. They plan to collect medical information and genetic material (DNA) from 400 families nationwide in which two or more siblings have AS. The project will be headed by John D. Reveille, M.D., of the University of Texas-Houston Health Science Center, along with investigators at nine other research centers and staff from the Spondylitis Association of America.

“We are encouraged by the possibilities for development of new approaches for the diagnosis and treatment of ankylosing spondylitis as a result of this research project," says Stephen I. Katz, M.D., Ph.D., director of the NIAMS.

Ankylosing spondylitis, also known as arthritis of the spine, is a rheumatic disease that causes inflammation of the tendons and ligaments around the bones and joints in the spine. The result is pain and stiffness, especially in the lower back. While AS primarily affects the spine, it can also cause inflammation in the hips, shoulders and knees. AS usually begins in late adolescence or early adulthood. The disease is primarily diagnosed in men; however, recently, diagnosis of AS among women has increased.

Treatment for AS is designed to reduce inflammation in the joints and maintain flexibility. Therapy includes nonsteroidal anti-inflammatory drugs such as ibuprofen, disease-modifying drugs such as sulfasalazine and methotrexate, and to a limited degree, antibiotics. In cases of spinal fusion, surgery is used to straighten the back and allow a person to stand upright; however, restoring original flexibility and function is not possible. There is no cure.

"Recent familial studies show genes other than HLA-B27 have possible implications for AS, " said Dr. Reveille, head of the coordinating center leading the study. "Mapping these genes may shed fundamental light on AS and other autoimmune diseases," he added. HLA-B27 is a part of a family of genes known to play a role in the function of that part of the immune system known as the major histocompatibility complex (MHC).
The consortium's goals begin with the recruitment of families in which two siblings have been diagnosed with AS. The Spondylitis Association of America will have a major role in recruitment of patients and also will maintain a central registry of information on families and sibling pairs with AS (including clinical, x-ray and laboratory data). At the University of Texas-Houston Health Science Center, researchers will establish a bank of sera (or blood), genomic DNA and frozen lymphocytes (or white blood cells) from the affected and unaffected sibling pairs, and–when available–both their parents.

Through genetic typing methods, researchers will search for additional alleles (or alternative forms of a gene) within the MHC that may contribute to predisposition of AS. In addition, they will conduct a genome-wide search for sibling pairs affected and unaffected by AS and map genes linked to AS that exist outside of the MHC. Finally, the research team hopes to identify, from newly mapped candidate genes, mutations and their effect on disease severity.
"We are pleased to be a part of this active ongoing partnership between an outstanding research team and the Spondylitis Association of America. This partnership is key to ensuring the success of this important project," said Dr. Katz.

Source: The National Institute of Arthritis and Musculoskeletal and Skin Diseases



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map