ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

Ginger Fights Obesity

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Eating more vegetable protein may protect against early menopause

Vitamin C and antibiotics: A new one-two 'punch' for knocking-out cancer stem cells

German Chamomile Oil: A Versatile Essential Oil You Should Have at Home

Print Page
Email Article

Clues found for early memory loss in Alzheimer's disease

  [ Not Yet Rated ]   [ Discuss This Article ]
By Press Release by the National Institutes of Health • • April 7, 1994

Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) have discovered that adding a substance called beta amyloid to normal skin cells causes the cells to exhibit the same type of molecular dysfunction previously demonstrated in skin cells of patients with Alzheimer's disease (AD). This step may lead to a new explanation of memory loss, one of the earliest and most common symptoms of the disease. The study will be published in the April 8, 1994 issue of Science.

By placing a solution of low-level beta amyloid in culture with normal human fibroblasts, or skin cells, the scientists produced changes in potassium channel function similar to changes observed in cells from AD patients. Last year, the same laboratory demonstrated that skin cells from people with AD have defects that upset the cell's ability to properly regulate potassium and calcium ions. The flow of potassium and consequent uptake of calcium are especially critical in cells responsible for memory formation and storage.
Beta amyloid is a protein that is the main component of plaques, the patches of destroyed brain tissue which, together with neurofibrillary tangles, are the classic hallmark of Alzheimer's disease.

"For many years scientists have been trying to understand the relationship between memory loss and plaques in the brain and, indeed, to determine what role beta amyloid plays in the early stages of AD. What this finding suggests is that soluble beta amyloid may cause the dysfunction that leads to memory loss even before the insoluble form congeals into plaques," said Daniel L. Alkon, M.D., chief of the NINDS Laboratory of Adaptive Systems, where the work was conducted, and an author of the paper.

"If we can understand what is happening in the cellular process early enough in the course of Alzheimer's disease, we may move closer to learning how to intervene and halt the deadly progression of this disease. This study points us in that direction," said Patricia A. Grady, Ph.D., Acting Director of NINDS.

The Science paper expands upon and validates the earlier study by Dr. Alkon's laboratory that described a possible skin test for diagnosing AD based on the differences found in the skin cells of AD patients. Their work was published in the Sept. 1, 1993 Proceedings of the National Academy of Sciences.** The earlier study showed that the skin cells of people with AD were missing a certain type of microscopic tunnel (the 113pS potassium channel) that governs the flow of potassium in and out of the cells. Of 44 people tested, skin cells from the 13 who were clinically diagnosed with AD were missing the potassium channel, whereas nearly all of the people in the control group had functional potassium channels of the same type.

In the current study, researchers found that after treating one group of the cells with soluble beta amyloid for 48 hours, the 113pS potassium channel was absent in all but one of the cells. However, the functional potassium channel was present in 94% of a group of untreated cells. After conducting a variety of similar tests, the scientists concluded that beta amyloid seems to selectively target this specific potassium channel, which they had observed to be absent in skin cells of AD patients.

"The fact that low concentrations of beta amyloid can disrupt the function of this key potassium channel may be a clue to what's happening in the brain to cause early memory loss in Alzheimer's patients," said Dr. Alkon. Researchers in Dr. Alkon's laboratory are now at work on the next step--to see if similar potassium channel dysfunction occurs in central nervous system neurons. The scientists have discovered similar defects in nerve cells of the olfactory system, suggesting that such defects may also be present in brain cells.

AD is the single greatest cause of intellectual impairment in older Americans, affecting more than 2.5 million people in the United States alone. The disorder causes a progressive and irreversible dementia, or mental decline.

Source: National Institutes of Health
US Department of Health and Human Service
Press Release
April 7, 1994

Reference: *Rene Etcheberrigaray, M.D., Etsuro Ito, Ph.D., Christopher S. Kim, Daniel L. Alkon, M.D. "Soluble b-Amyloid Induction of Alzheimer's Phenotype for Human Fibroblast K+ Channels," Science, Vol. 264, April 8, 1994 (pp. 276-278).
**Rene Etcheberrigaray, Etsuro Ito, Kotaro Oka, Beth Tofel-Grehl, Gary E. Gibson and Daniel L. Alkon. "Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease," PNAS, Sept. 1, 1993 (pp. 8209-8213).

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map