ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

How Can You Benefit From Vitamin B12?

Calorie restriction promotes longevity through effects on mitochondrial network

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

What Is Bitter Orange?

Black Tea Is Great for Your Gut

Drug can dramatically reduce weight of people with obesity

Tryptophan's Possible Effects for Your Health

New Finding: Broccoli Helps Heal Leaky Gut

 
Print Page
Email Article

Dementia With Lewy Bodies and in relation to Alzheimer’s Disease

  [ Not Yet Rated ]   [ Discuss This Article ]
By Report by the AD Educ and Referral Ctr • www.ProHealth.com • September 1, 1998


Fatal attractions between otherwise normal proteins seem to be a common theme in Alzheimer's disease (AD) and a diverse group of disorders related to AD. National Institute on Aging (NIA)-supported researchers at the University of Pennsylvania Alzheimer's Disease Center (ADC) are interested in abnormal protein interactions in AD and related dementias. According to two researchers at this ADC, Drs. John Q. Trojanowski and Virginia M.-Y. Lee, "These proteins are attracted to each other through positive and negative charges. They then stick together and cause toxic lesions (see Key Terms) to form. That is, the proteins get all bunched up together, fatally injuring the cell."

These researchers are looking at Lewy bodies (LBs) and their relationship to AD. LBs are a hallmark of Parkinson's disease (PD). Recently, scientists identified LBs in the brains of patients with standard AD features (amyloid plaques and neurofibrillary tangles). In addition, LBs have been found in the brains of patients with AD-like dementia, but with sparse or no signs of AD pathology. These types of disorders with LBs collectively are called "dementia with Lewy bodies" (DLB).

Dr. Kenji Kosaka first described DLB in 1978. Several research groups in the United States and United Kingdom have reported DLB as the second most common form of dementia in older people, next to AD.

How and why LBs and AD develop are unknown. Researchers now are able to identify LBs under a microscope, but their exact makeup and role in AD remain unclear. To answer these questions, Drs. Trojanowski and Lee are studying abnormal protein buildup and neuron death in PD and DLB.

These and other scientists have found that abnormal protein interactions cause protein filaments to form and build up; this is called filament accumulation. These toxic brain lesions are a common feature of some sporadic and hereditary dementias. Such interactions may play a role in the development of amyloid plaques and neurofibrillary tangles, which are characteristic of both sporadic and familial AD. These same interactions also may play a role in the formation of prion protein deposits found in the brains of patients with sporadic and genetic spongiform encephalopathy.

According to Dr. Trojanowski, "We want to draw attention to parallels among the lesions you find in AD, PD, prion disease, tauopathies, and other diseases. Some lesions are outside cells (extracellular) and others are inside (intracytoplasmic), but the central theme is filament accumulation. Another parallel is that these lesions are created from proteins, such as alpha-synuclein, but not the same protein in each disease. They all start out as normal (healthy functioning) proteins that, for some unknown reason, change from being soluble to insoluble or from good to bad."

Source: Connections Magazine [Volume 7(2), Fall 1998]



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
The Cellular Enzyme That Promotes Longevity And Reduces Fat Storage The Cellular Enzyme That Promotes Longevity And Reduces Fat Storage
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map