ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Curcumin Supplementation May Impart Long-Term Cognitive Benefits

 
Print Page
Email Article

Comparison of EIA Borrelia recombinant IgM of the 3rd generation with EIA test based on whole cell antigen in the diagnosis of Lyme borreliosis.

  [ Not Yet Rated ]   [ Discuss This Article ]
By Krbková L, Stroblová H • www.ProHealth.com • December 1, 2004


Abstract

OBJECTIVES: Evaluation of a new kit of the 3rd generation, EIA Borrelia recombinant IgM in the serodiagnosis of Lyme borreliosis (LB) and comparison with the EIA test based on the whole cell antigen in the detection of IgM antibodies.

MATERIAL AND METHODS: In total 123 children (147 sera) were examined, 71 children (93 sera) of whom showed clinically defined stage of LB. The other 54 sera of 52 children were tested for suspicion for LB which was later excluded, and for cross-reacting antibodies. They represented the control group of children with other infectious or autoimmune diseases. The EIA B. recombinant IgM kit (Test-Line, CR) is based on the selected antigen fragments: outer surface protein C (OspC) and internal flagellin (p41i). The fragments were selected according to the most frequent Borrelia spp. in the Czech Republic.

RESULTS: Samples compared 101/147 (69 %) with both tests showed correspondent reactions. 46 samples reacted inconsistently, 26 from children with LB and 20 from the control group. The total specificity and sensitivity of the recombinant kit in IgM antibody class was 88,9 % and 26,9 %, respectively. In the case of early disseminated LB infection the sensitivity was 35,6 % and it is comparable with the sensitivity of immunoblot. Statistically, there is no difference in the sensitivity (p = 0,101) and specificity (p = 0,383) of EIA B. recombinant IgM and immunoblot.

CONCLUSIONS: The EIA B. recombinant IgM kit shows comparable diagnostic sensitivity in children with acute LB together with significantly higher specificity in children with non-specific response in kits based on the whole cell antigen and at the same time high conformity with results of IgM class immunoblot. This kit of the 3rd generation is reliable for screening of IgM antibodies.

Klin Mikrobiol Infekc Lek. 2004 Dec;10(6):271-8. Comparative Study; English Abstract





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map