ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

More evidence for calorie restriction’s longevity effect

Vitamin D deficiency increases risk of chronic headache

Wearable biosensors can flag illness, Lyme disease, risk for diabetes; low airplane oxygen

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

The Role of ApoE in Sporadic AD

  [ Not Yet Rated ]   [ Discuss This Article ]
By Report by the AD Educ & Referral Ctr • www.ProHealth.com • March 21, 1996


Some confusion surrounds sporadic AD, which is far more common than FAD. Sporadic AD is related to the apoE gene found on chromosome 19.

ApoE comes in three different forms or alleles. People inherit one allele (apoE2, apoE3, or apoE4) on the apoE gene on chromosome 19 from each parent. People with both apoE3 and apoE4 alleles (E3/4) are affected by both alleles.
Having one or two copies of the E4 allele may increase a person's risk of getting AD. That is, having the E4 allele of the apoE gene is a risk factor for AD. But, it does not mean that AD is inevitable. Having one or two E4 alleles of the apoE gene increases risk of AD, but not to 100 percent. Some people with two copies of the E4 allele (the highest risk group) have not developed the disease, and others with no E4's have. Scientists have yet to determine the exact degree of risk of AD for any given person based on apoE status.

Dr. Allen Roses and his colleagues at the Duke University Alzheimer's Disease Center in Durham, North Carolina, studied 72 families to see how a person's apoE status relates to age of onset for AD. Participants included 158 people with late-onset, sporadic AD (affected) and 220 without (unaffected). At age 70, 50 percent of those with E4/4 remained unaffected. At the same age, 72 percent of those with E3/4 and 94 percent of those with E2/4 and E3/3 remained unaffected. Also at age 70, 100 percent of those with E2/3 remained unaffected.

ApoE Testing -- A blood test is available to assess apoE status because the allele also is associated with heart disease, which has been well studied. However, this blood "test" cannot tell people whether they will develop the disease. Instead of a "yes" or "no" answer, the best information one can get from genetic assessment for apoE is "maybe" or "maybe not."

Many questions remain at this time about the usefulness of apoE testing in non-research settings. Some researchers predict that the best use of apoE testing will be as part of a complete patient assessment, rather than as a stand-alone test for AD.

Source: Connection Magazine [Volume 5(1), Winter/Spring 1996]



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Break Free From Fibromyalgia Break Free From Fibromyalgia
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Enhance Eyelashes Naturally Enhance Eyelashes Naturally

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map