ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

Tryptophan's Possible Effects for Your Health

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Mint: Learn More About This Refreshing and Invigorating Herb

 
Print Page
Email Article

The Role of ApoE in Sporadic AD

  [ Not Yet Rated ]   [ Discuss This Article ]
By Report by the AD Educ & Referral Ctr • www.ProHealth.com • March 21, 1996


Some confusion surrounds sporadic AD, which is far more common than FAD. Sporadic AD is related to the apoE gene found on chromosome 19.

ApoE comes in three different forms or alleles. People inherit one allele (apoE2, apoE3, or apoE4) on the apoE gene on chromosome 19 from each parent. People with both apoE3 and apoE4 alleles (E3/4) are affected by both alleles.
Having one or two copies of the E4 allele may increase a person's risk of getting AD. That is, having the E4 allele of the apoE gene is a risk factor for AD. But, it does not mean that AD is inevitable. Having one or two E4 alleles of the apoE gene increases risk of AD, but not to 100 percent. Some people with two copies of the E4 allele (the highest risk group) have not developed the disease, and others with no E4's have. Scientists have yet to determine the exact degree of risk of AD for any given person based on apoE status.

Dr. Allen Roses and his colleagues at the Duke University Alzheimer's Disease Center in Durham, North Carolina, studied 72 families to see how a person's apoE status relates to age of onset for AD. Participants included 158 people with late-onset, sporadic AD (affected) and 220 without (unaffected). At age 70, 50 percent of those with E4/4 remained unaffected. At the same age, 72 percent of those with E3/4 and 94 percent of those with E2/4 and E3/3 remained unaffected. Also at age 70, 100 percent of those with E2/3 remained unaffected.

ApoE Testing -- A blood test is available to assess apoE status because the allele also is associated with heart disease, which has been well studied. However, this blood "test" cannot tell people whether they will develop the disease. Instead of a "yes" or "no" answer, the best information one can get from genetic assessment for apoE is "maybe" or "maybe not."

Many questions remain at this time about the usefulness of apoE testing in non-research settings. Some researchers predict that the best use of apoE testing will be as part of a complete patient assessment, rather than as a stand-alone test for AD.

Source: Connection Magazine [Volume 5(1), Winter/Spring 1996]



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Optimized Curcumin Longvida® Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map