ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Potential of Quercetin in the Treatment of Melanoma

Trimming the spare tire: Canola oil may cut belly fat

Supplementation with vitamins C and E associated with decreased risk of cognitive impairment, dement...

 
Print Page
Email Article

Newly Identified Antibiotic Protein Kills Intestinal Bacteria

  [ 177 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 29, 2003


Researchers at Washington University School of Medicine in St. Louis have discovered a new antibiotic protein that appears to kill certain types of bacteria in the intestine. Their results are published Jan. 27 in the online version of the journal Nature Immunology and are slated for print publication in March.

"These findings were completely unexpected," says Lora V. Hooper, Ph.D., instructor of molecular biology and pharmacology. "We initially thought that this protein might be involved in blood vessel formation. What we discovered, though, is that it's a potent killer of bacteria."

Hooper is first author of the study; Jeffrey I. Gordon, M.D., the Dr. Robert J. Glaser Distinguished University Professor and Head of the Department of Molecular Biology and Pharmacology, led the study.

The team identified a protein called angiogenin 4 (Ang4), which belongs to a class of proteins originally believed to be involved in the development of blood vessels that supply tumors with nutrients. The group discovered that Ang4 was released by specific cells, called Paneth cells, located in the intestinal lining.

Because Paneth cells are known to assist the immune system in defending against infection, the team examined Ang4 to determine how it interacts with a variety of different microbes. They found that the protein killed certain kinds of gut microbes and conclude that Ang4 may be part of an arsenal of microbicidal proteins deployed by Paneth cells to help keep gut bacteria from getting too close to the intestinal lining, where they could cause damage or mount an invasion.

Moreover, the researchers were surprised to find production of Ang4 is controlled by a bacterium that makes its home in the intestine. The microbe, called Bacteroides thetaiotaomicron, is a prominent member of the mouse and human gut microbial community. This makes Ang4 unique, as it is the first example of a protein antibiotic whose expression is controlled by friendly intestinal bacteria.

"Robert Frost said it best: 'Good fences make good neighbors,'" Hooper says. "Apparently, one of the functions of normal gut bacteria is to help erect an "electric fence" that protects the internal milieu from microbes we encounter throughout our lives."
The group also discovered that other mouse and human angiogenins, which are produced in other organs, also are able to combat dangerous microorganisms.

"These findings support the notion that the angiogenin family of proteins may represent a critical component of the body's innate defense system," Gordon says.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map