ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

Trial Finds Reduction in Depressive Symptoms Following Magnesium Supplementation

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Hop Oil: A Safe Sleep Aide

White Camphor Oil: The Purest Camphor Oil

Lutein — An Important Nutrient for Eye and Brain Health

Print Page
Email Article

Alzheimer protein found critical to brain development

  [ 27 votes ]   [ Discuss This Article ]
By Press Release by the Univ. of Toronto • • October 31, 1999

Researchers from Mount Sinai Hospital's Samuel Lunenfeld Research Institute and the University of Toronto have discovered that some of the proteins responsible for familial Alzheimer's disease are also critical to mammalian development. The study is published in the November 1st edition of the journal Genes and Development.

Previous work in Toronto by Dr. Peter St. George Hyslop and others has shown that the human genes Presenilin 1 (PS1) and Presenilin 2 (PS2) are responsible for certain hereditary forms of Alzheimer's. To investigate how these proteins normally function, the Lunenfeld scientists developed mice lacking PS1 and PS2. These mutant mice do not survive past the early embryonic stage of development due to multiple defects, including brain development.

"The study shows that the same proteins that malfunction late in life have a key role in the beginning of life," said study author Dr. Alan Bernstein, director of the Samuel Lunenfeld Research Institute of Toronto's Mount Sinai Hospital and professor of medical genetics at the University of Toronto.
Post-doctoral researcher Dr. Dorit Donoviel, also of the Lunenfeld, said mice were used in the study because they are genetically and biochemically similar to humans. "These observations raise the intriguing possibility that early decisions in human development can have serious effects late in life," Dr. Donoviel says. "These mice will provide a valuable biological tool with which to understand the function of the molecules implicated in Alzheimer's Disease."

According to the Alzheimer Society of Canada there is no known cure for the disease that destroys vital nerve cells in the brain. Alzheimer Disease is the most common form of dementia, which affects 316,500 Canadians. The number is expected to grow to 750,000 Canadians affected by the year 2031.

The other study authors are: Anna-Katerina Hadjantonakis, Samuel Lunenfeld Research Institute of Mount Sinai Hospital; Masaki Ikeda, Centre for Research in Neurodegenerative Diseases and department of medicine, division of neurology, University of Toronto; Hui Zheng, Merck Research Laboratories, Rahway, New Jersey; Peter St. George Hyslop, Centre for Research in Neurodegenerative Diseases and department of medicine, division of neurology, University of Toronto and Toronto Western Hospital.

Source: University of Toronto Press Release: October 31, 1999

Contact: Steven de Sousa,, 416-978-5949

Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® FibroSleep™

Article Comments

Be the first to comment on this article!

Post a Comment

NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Safely Burn Away Body Fat Safely Burn Away Body Fat

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map