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Peptide-based OspC enzyme-linked immunosorbent assay for serodiagnosis of Lyme borreliosis.

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By Mathiesen MJ, Christiansen M, Hansen K, Holm A, Asbrink E, Theisen M • www.ProHealth.com • December 1, 1998


Abstract

Sera from 210 patients with Lyme borreliosis (LB) were studied by an enzyme-linked immunosorbent assay (ELISA) based on a synthetic peptide (pepC10) comprising the C-terminal 10-amino-acid residues of OspC of Borrelia burgdorferi. We found that 36.3 and 45.0% of the serum samples from patients with erythema migrans (EM) and neuroborreliosis (NB), respectively, displayed immunoglobulin M (IgM) anti-pepC10 reactivities, while these samples rarely (

J Clin Microbiol. 1998 Dec;36(12):3474-9. Research Support, Non-U.S. Gov't





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