ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

What’s Fenugreek Good For?

Omega-3 fatty acid stops known trigger of lupus

Print Page
Email Article

Researchers develop novel mouse model of Alzheimer's disease

  [ Not Yet Rated ]   [ Discuss This Article ]
By Press Release by Case Western Reserve Univ • • July 20, 1999

An obstacle to understanding how Alzheimer's disease develops has been the lack of an accurate animal model for scientific study. Now, scientists in Cleveland report that they have developed novel genetically engineered mice that exhibit pathological characteristics of Alzheimer's disease. These mice will likely provide new insights into the disease and its treatment.

In work to be published in the August issue of the journal Nature Neuroscience, Bruce Lamb, assistant professor of genetics, and colleagues at Case Western Reserve University's School of Medicine and University Hospitals of Cleveland created the lines of mice using yeast artificial chromosomes to transfer pieces of human DNA into mice. The researchers incorporated into the mice entire copies of human genes that result in early-onset Alzheimer's disease in humans.

One gene encodes amyloid precursor protein (APP), the protein that gives rise to the characteristic amyloid deposits (beta-amyloid proteins) that occurs in the brains of Alzheimer's disease patients. The other gene encodes presenilin-1 (PS-1), a protein that has been implicated in the biochemical processing of APP.

The researchers found that mice carrying the mutant form of APP developed amyloid deposits similar to those found in patients with Alzheimer's disease. Moreover, mice with two copies of the APP gene, or with both mutant genes, developed even more deposits.

"Higher levels of beta-amyloid protein are vital for the appearance of Alzheimer's disease pathology in mice, similar to what has been observed in humans with the genetic forms of the disease," said Lamb, who is also affiliated with the University Alzheimer Center in Cleveland. "In addition, further elevation of the levels of beta-amyloid accelerates the age of onset of pathological changes observed in the mice."

He said that additional experiments will be necessary to determine the relationship between the pathology observed in these transgenic mice and other characteristic signs of the disease, including neuronal cell loss and deficits in cognitive function.

"But as these mice contain the entire human genes involved in Alzheimer's disease, as opposed to smaller portions of the genes employed by other investigators, they will likely provide unique insights into the mechanism and progression of Alzheimer's disease in humans as well as provide a novel small animal model for testing therapeutics," Lamb said.

Funding supporting the work came from the National Institutes of Health, the American Health Assistance Foundation, and the Bristol-Meyers Squibb Pharmaceutical Research Institute.

Source: Case Western Reserve University Press Release: July 20, 1999

Contact: George Stamatis,, 216-368-3635

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Vitamin D3 Extreme™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map